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  4. Recombinant Human Protein L-Myc (MYCL), partial

Recombinant Human Protein L-Myc (MYCL), partial

  • 中文名称：
    Recombinant Human Protein L-Myc (MYCL), partial
  • 货号：
    CSB-EP015274HU1
  • 规格：
    ￥1536
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    MYCL
  • Uniprot No.：
    P12524
  • 别名：
    Class E basic helix-loop-helix protein 38;bHLHe38;Protein L-Myc-1;V-myc myelocytomatosis viral oncogene homolog
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    29.4 kDa
  • 表达区域：
    242-364aa
  • 氨基酸序列
    AAGEKEDEEDEEIVSPPPVESEAAQSCHPKPVSSDTEDVTKRKNHNFLERKRRNDLRSRFLALRDQVPTLASCSKAPKVVILSKALEYLQALVGAEKRMATEKRQLRCRQQQLQKRIAYLTGY
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-KSI-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

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MYCL Proteins

靶点详情

  • 基因功能参考文献：
    1. These results suggest that Mycl1 expression might be useful as a biomarker to predict prognosis and is a promising therapeutic target for patients with gastric cancer. PMID: 25528583
    2. Several tagging SNPs and haplotypes in TRIT1, MYCL1 and MFSD2A region are significantly associated with risk and clinicopathological features of gastric cancer in a Chinese population. PMID: 23349019
    3. The polymorphism of H-ras and L-myc genes is not related to colorectal cancer risk, but there is a synergy between H-ras and L-myc polymorphisms in the development of rectal cancer. PMID: 22490849
    4. MYCL1 is the target of hsa-miR-1827. A rs3134615 G>T SNP in the 3'-UTR altered regulation of MYCL1 expression. This SNP was associated with increased susceptibility to SCLC, possibly resulting from attenuated interaction with the miRNA hsa-miR-1827. PMID: 21676885
    5. The results demonstrate that MYCL1 rs3134613 is associated with susceptibility to diffuse-type gastric cancer and with differentiation of gastric cancer. PMID: 20874233
    6. L-myc polymorphism may affect the induction of lung cancer by smoking PMID: 11802801
    7. L-myc proto oncogene RFLP is associated with lung adenocarcinoma PMID: 11836605
    8. Allelic deletions of L-myc in urine from bladder cancer patients PMID: 11956626
    9. MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmoary fibrosis PMID: 12169206
    10. Colorectal tumor patients whose tumors exhibited loss of heterozygosity at MYCL1 at chromosome 1p34 were likely to have a poor prognosis. PMID: 15014029
    11. polymorphisms in the MYCL1 LD region affect lung cancer survival but that the functional element(s) may show population-specific patterns PMID: 17145094
    12. L-myc gene polymorphism may have a role in risk of thyroid cancer PMID: 18566574
    13. The L-myc gene polymorphism may help detect and prevent HNNMSC and LLC in susceptible individuals. It may also contribute to estimation of tumor behavior in patients with HNNMSC. PMID: 18645122
    14. L-Myc may have a role in Merkel cell carcinoma pathogenesis PMID: 19020549

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 7555

    OMIM: 164850

    KEGG: hsa:4610

    STRING: 9606.ENSP00000380494

    UniGene: Hs.437922

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