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  4. Recombinant Human Piwi-like protein 3 (PIWIL3), partial

Recombinant Human Piwi-like protein 3 (PIWIL3), partial

  • 中文名称：
    人PIWIL3重组蛋白
  • 货号：
    CSB-YP773785HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PIWIL3重组蛋白
  • 货号：
    CSB-EP773785HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PIWIL3重组蛋白
  • 货号：
    CSB-EP773785HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PIWIL3重组蛋白
  • 货号：
    CSB-BP773785HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PIWIL3重组蛋白
  • 货号：
    CSB-MP773785HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PIWIL3
  • Uniprot No.：
    Q7Z3Z3
  • 别名：
    HIWI3; Piwi like 3; Piwi-like protein 3; piwi-like RNA-mediated gene silencing 3; PIWIL3; PIWL3_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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PIWIL3 antibodies

靶点详情

  • 功能：
    May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation.
  • 基因功能参考文献：
    1. overexpression of Piwil3 promotes the proliferation, migration and invasion of GC cells partially through JAK2/STAT3 signal pathway. PMID: 28869440
    2. Our data indicate that PIWIL3 protein expression is elevated in more aggressive primary malignant melanoma(MM )and metastatic disease. As also observed in other malignancies, PIWIL3 seems to play a role in MM progression. PMID: 27858163
    3. individuals with HIWI3 non-synonymous rs11703684 variant genotypes exhibited a significantly reduced oligozoospermia risk PMID: 20940137
    4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20940137
    5. PIWIL3 proteins were expressed in the cytoplasma of human astrocytic glioma and meningioma. PMID: 18616918

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Argonaute family, Piwi subfamily
  • 组织特异性：
    Expressed in testis.
  • 数据库链接：

    HGNC: 18443

    OMIM: 610314

    KEGG: hsa:440822

    STRING: 9606.ENSP00000330031

    UniGene: Hs.448343

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