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  4. Recombinant Human Oxysterol-binding protein 2 (OSBP2), partial

Recombinant Human Oxysterol-binding protein 2 (OSBP2), partial

  • 中文名称：
    人OSBP2重组蛋白
  • 货号：
    CSB-YP856888HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人OSBP2重组蛋白
  • 货号：
    CSB-EP856888HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人OSBP2重组蛋白
  • 货号：
    CSB-EP856888HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人OSBP2重组蛋白
  • 货号：
    CSB-BP856888HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人OSBP2重组蛋白
  • 货号：
    CSB-MP856888HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    OSBP2
  • Uniprot No.：
    Q969R2
  • 别名：
    OSBP2; KIAA1664; ORP4; OSBPL4; Oxysterol-binding protein 2; Oxysterol-binding protein-related protein 4; ORP-4; OSBP-related protein 4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds 7-ketocholesterol.
  • 基因功能参考文献：
    1. The authors uncovered a signalling pathway operating specifically in T-cell acute lymphoblastic leukemia cells in which ORP4L mediates G protein-coupled ligand-induced PLCbeta3 activation, resulting in an increase of mitochondrial respiration for cell survival. PMID: 27581363
    2. High ORP4L expression is associated with cervical carcinoma. PMID: 27588468
    3. ORP4L is crucial for macrophage survival and plays a role in the development of atherosclerosis. PMID: 27729467
    4. ORP4 promotes the survival of rapidly proliferating cells. PMID: 24742681
    5. Inhibition of HCV replication by oxysterol-binding protein-related protein 4 (ORP4) through interaction with HCV NS5B and alteration of lipid droplet formation. PMID: 24069433
    6. In preliminary results, significantly higher levels of OSBP2 and OSBPL-7 mRNA were seen in blood samples from cholangiocarcinoma patients than in healthy controls. PMID: 21763455
    7. OSBP2 has a role in chronic myeloid leukemia PMID: 12964051
    8. Thus the sterol-binding domain of ORP4 binds vimentin, cholesterol and oxysterols, and interacts with the filamentous vimentin network. PMID: 17350617
    9. a possible role of OSBP2 gene in the pathogenesis of oxidative damage to the macula induced by oxysterols in age-related macular degeneration patients. PMID: 18294060

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  • 亚细胞定位：
    Membrane; Peripheral membrane protein.
  • 蛋白家族：
    OSBP family
  • 组织特异性：
    Expressed mainly in retina, testis, and fetal liver.
  • 数据库链接：

    HGNC: 8504

    OMIM: 606729

    KEGG: hsa:23762

    STRING: 9606.ENSP00000332576

    UniGene: Hs.517546

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