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  4. Recombinant Human Nuclear body protein SP140 (SP140), partial

Recombinant Human Nuclear body protein SP140 (SP140), partial

  • 中文名称：
    人SP140重组蛋白
  • 货号：
    CSB-YP623798HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SP140重组蛋白
  • 货号：
    CSB-EP623798HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SP140重组蛋白
  • 货号：
    CSB-EP623798HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SP140重组蛋白
  • 货号：
    CSB-BP623798HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SP140重组蛋白
  • 货号：
    CSB-MP623798HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SP140
  • Uniprot No.：
    Q13342
  • 别名：
    LY10_HUMAN; Lymphoid restricted homolog of Sp100; Lymphoid specific SP100 homolog; Lymphoid-restricted homolog of Sp100; LYSP100 A; LYSp100; LYSP100 B; LYSp100 protein; LYSP100-A; LYSP100-B; LYSP100A; LYSP100B; MGC126440; Nuclear antigen Sp140; Nuclear autoantigen Sp-140; Nuclear autoantigen Sp140; Nuclear body protein SP140; SP140; SP140 nuclear body protein; SP140 PEN; Speckled 140 kDa
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails.
  • 基因功能参考文献：
    1. IL1R2 hypomethylation and androgen receptor hypermethylation may constitute an important determinant of disease severity, whereas NPR2 hypomethylation and SP140 hypermethylation may provide a biomarker for vulnerability to excessive daytime sleepiness in Obstructive Sleep Apnea PMID: 26888452
    2. Data identified rs28445040 variant in SP140 gene as the causal factor for skipping of exon 7 and the most associated with multiple sclerosis. PMID: 26152201
    3. the nuclear body protein Sp140, was found specifically in all NP cells (n = 12 cell lines tested; P < or = 0.001), and HIV-1 infection induced its partial dispersal from nuclear bodies into cytosolic colocalization with Vif PMID: 12368356
  • 亚细胞定位：
    Nucleus. Nucleus, PML body. Cytoplasm.
  • 组织特异性：
    High levels in spleen and peripheral blood leukocytes, much lower levels in tonsils, thymus, prostate, ovary, small intestine, and colon Very low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not detected in brain,
  • 数据库链接：

    HGNC: 17133

    OMIM: 608602

    KEGG: hsa:11262

    STRING: 9606.ENSP00000375899

    UniGene: Hs.632549

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