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  4. Recombinant Human Neurobeachin (NBEA), partial

Recombinant Human Neurobeachin (NBEA), partial

  • 中文名称：
    人NBEA重组蛋白
  • 货号：
    CSB-YP015482HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NBEA重组蛋白
  • 货号：
    CSB-EP015482HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NBEA重组蛋白
  • 货号：
    CSB-EP015482HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NBEA重组蛋白
  • 货号：
    CSB-BP015482HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NBEA重组蛋白
  • 货号：
    CSB-MP015482HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NBEA
  • Uniprot No.：
    Q8NFP9
  • 别名：
    BCL8B; FLJ10197; KIAA1544; Lysosomal trafficking regulator 2; Lysosomal-trafficking regulator 2; LYST2; NBEA; NBEA_HUMAN; Neurobeachin; Protein BCL8B; Protein neurobeachin; RP11-270C18.1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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NBEA antibodies

靶点详情

  • 功能：
    Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins.
  • 基因功能参考文献：
    1. NBEA encodes neurobeachin: we found no evidence of association in data from the GWAS migraine meta-analysis consortium (n=118,710 participants) suggesting that the association might be specific to migraine co-morbid with bipolar disorder. PMID: 25451450
    2. Data indicate that the PVT1-NBEA and the PVT1-WWOX chimeric genes were associated with the expression of abnormal NBEA and WWOX. PMID: 22869583
    3. Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin. PMID: 22745750
    4. data obtained in mice and humans suggest that variation of Nbea abundance or activity critically affects body weight, presumably by influencing the activity of feeding-related neural circuits PMID: 22438821
    5. Structural analysis and biochemical studies show that the PH and BEACH domains have strong interactions, suggesting they may function as a single unit. PMID: 12234919
    6. neurobeachin encoding gene is disrupted in a patient with a de novo translocation t(5;13) (q12.1;q13.2), idiopathic autism, and no family history of autism PMID: 12746398
    7. The NBEA gene at 13q13, and its expression are frequently disrupted in MM. PMID: 19135901

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    WD repeat neurobeachin family
  • 组织特异性：
    Predominant in many brain structures. Also expressed at medium levels in spleen, thymus, prostate, testis and ovary. Low level expression is seen in heart, kidney, pancreas, skeletal muscle and intestine.
  • 数据库链接：

    HGNC: 7648

    OMIM: 604889

    KEGG: hsa:26960

    STRING: 9606.ENSP00000383295

    UniGene: Hs.491172

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