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  4. Recombinant Human Intraflagellar transport protein 88 homolog (IFT88), partial

Recombinant Human Intraflagellar transport protein 88 homolog (IFT88), partial

  • 中文名称：
    人IFT88重组蛋白
  • 货号：
    CSB-YP618756HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人IFT88重组蛋白
  • 货号：
    CSB-EP618756HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人IFT88重组蛋白
  • 货号：
    CSB-EP618756HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人IFT88重组蛋白
  • 货号：
    CSB-BP618756HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人IFT88重组蛋白
  • 货号：
    CSB-MP618756HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    IFT88
  • Uniprot No.：
    Q13099
  • 别名：
    D13S1056E; DAF19; hTg737; Ift88; IFT88_HUMAN; Intraflagellar transport 88 homolog; Intraflagellar transport protein 88 homolog; MGC26259; Polaris homolog; Probe hTg737 (polycystic kidney disease; autosomal recessive); Recessive polycystic kidney disease protein Tg737 homolog; RP11-172H24.2; Tetratricopeptide repeat domain 10; Tetratricopeptide repeat protein 10; TG737; TPR repeat protein 10; TTC10
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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IFT88 antibodies

靶点详情

  • 功能：
    Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
  • 基因功能参考文献：
    1. BFGF also upregulated the mRNA and protein expression of IFT88 in primary cultured chondrocytes. PMID: 28901443
    2. Data suggest that the function of the fusion transcript crystallin, lambda 1 protein - intraflagellar transport 88 (CRYL1-IFT88) is closed to CRYL1 because it contained most of domain of CRYL1. PMID: 28489570
    3. multivariate Cox regression analyses demonstrated that Tg737 expression was an independent factor for predicting the overall survival of hepatocellular carcinoma patients PMID: 28663060
    4. MiR-548a-5p negatively regulates the tumor inhibitor gene Tg737 and promotes tumorigenesis in vitro and in vivo, indicating its potential as a novel therapeutic target for hepatocellular carcinoma. PMID: 27340352
    5. subtle regulation of IFT and associated cilia structure, tunes the wnt response controlling stem cell differentiation. PMID: 24346024
    6. this work suggests that Tg737 is involved in the invasion and migration of hepatoma cells under hypoxia, with the involvement of the polycystin-1, IL-8, and TGF-beta1 signaling pathway PMID: 22974282
    7. A mutation in IFT88 causes a hitherto unknown human ciliopathy. PMID: 22941275
    8. Data show that IFT88 depletion induces mitotic defects in human cultured cells, in kidney cells from the IFT88 mouse mutant Tg737(orpk) and in zebrafish embryos. PMID: 21441926
    9. The results indicate that loss of heterozygosity of the tumor suppressor gene Tg737 may play an important role in the carcinogenetic mechanism of liver cancer stem cells. PMID: 20300861
    10. IFT88 is a centrosomal protein regulating G1-S transition in non-ciliated cells. PMID: 17264151

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium, flagellum.
  • 组织特异性：
    Expressed in the heart, brain, liver, lung, kidney, skeletal muscle and pancreas.
  • 数据库链接：

    HGNC: 20606

    OMIM: 600595

    KEGG: hsa:8100

    STRING: 9606.ENSP00000323580

    UniGene: Hs.187376

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