Your Good Partner in Biology Research

中文简体

CSF2｜ CTLA4｜ DLL3｜ EGFR｜ IL4｜ IL4R｜ LAG3｜ MSTN｜ NECTIN4｜ NT5E｜ SEZ6｜ TM4SF1｜ TNFSF13｜ TPO

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human E3 ubiquitin-protein ligase RLIM (RLIM)

Recombinant Human E3 ubiquitin-protein ligase RLIM (RLIM)

  • 中文名称：
    人RLIM重组蛋白
  • 货号：
    CSB-YP873666HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人RLIM重组蛋白
  • 货号：
    CSB-EP873666HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人RLIM重组蛋白
  • 货号：
    CSB-EP873666HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人RLIM重组蛋白
  • 货号：
    CSB-BP873666HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人RLIM重组蛋白
  • 货号：
    CSB-MP873666HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    RLIM
  • Uniprot No.：
    Q9NVW2
  • 别名：
    E3 ubiquitin-protein ligase RLIM; LIM domain-interacting RING finger protein; R-LIM; Renal carcinoma antigen NY-REN-43; RING finger LIM domain-binding protein; RING finger protein 12; RLIM; RNF12; RNF12_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-624
  • 氨基酸序列
    MENSDSNDKG SGDQSAAQRR SQMDRLDREE AFYQFVNNLS EEDYRLMRDN NLLGTPGEST EEELLRRLQQ IKEGPPPQNS DENRGGDSSD DVSNGDSIID WLNSVRQTGN TTRSGQRGNQ SWRAVSRTNP NSGDFRFSLE INVNRNNGSQ NSENENEPSA RRSSGENVEN NSQRQVENPR SESTSARPSR SERNSTEALT EVPPTRGQRR ARSRSPDHRR TRARAERSRS PLHPMSEIPR RSHHSISSQT FEHPLVNETE GSSRTRHHVT LRQQISGPEL LSRGLFAASG TRNASQGAGS SDTAASGEST GSGQRPPTIV LDLQVRRVRP GEYRQRDSIA SRTRSRSQTP NNTVTYESER GGFRRTFSRS ERAGVRTYVS TIRIPIRRIL NTGLSETTSV AIQTMLRQIM TGFGELSYFM YSDSDSEPTG SVSNRNMERA ESRSGRGGSG GGSSSGSSSS SSSSSSSSSS SSSSSSPSSS SGGESSETSS DLFEGSNEGS SSSGSSGARR EGRHRAPVTF DESGSLPFLS LAQFFLLNED DDDQPRGLTK EQIDNLAMRS FGENDALKTC SVCITEYTEG NKLRKLPCSH EYHVHCIDRW LSENSTCPIC RRAVLASGNR ESVV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

相关产品

RLIM antibodies

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
  • 基因功能参考文献：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that RLIM is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. missense mutation in RLIM gene was identified in four males with intellectual disability from a three-generation family. PMID: 25735484
    3. RNF12 is a novel positive regulator of p53 pathway and an external E3 ubiquitin ligase for MDM2 destruction. PMID: 26926424
    4. Rlim is a novel regulator of Stathmin protein in a ubiquitin-dependent manner, and represents a new pathway for malignant phenotype turnover by modulating the level of Stathmin protein in human osteosarcomas. PMID: 24686088
    5. hus regulated nucleocytoplasmic shuttling of RLIM/Rnf12 coordinates cellular compartments during mammary alveolar cell survival PMID: 23904271
    6. TP53 does not directly bind to the RLIM promoter, it physically interacts with and prevents the binding of Sp1 to the RLIM promoter. PMID: 23650532
    7. these results indicated that RLIM is an important positive regulator in TGF-beta signaling pathway and cell migration. PMID: 21945933
    8. RLIM represents a new pathway for telomere maintenance by modulating the level of TRF1 at telomeres. PMID: 19164295
    9. These findings provide evidence for a dose-dependent role of RNF12 in the XCI counting and initiation process. PMID: 19945382
    10. Functional analysis of the Xenopus homolog PMID: 12874135

    显示更多

    收起更多

  • 相关疾病：
    Mental retardation, X-linked 61 (MRX61)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    RNF12 family
  • 组织特异性：
    Expressed in many tissues.
  • 数据库链接：

    HGNC: 13429

    OMIM: 300379

    KEGG: hsa:51132

    STRING: 9606.ENSP00000253571

    UniGene: Hs.653288

Most popular with customers

产品中心
特别关注


X
九游平台-九游(中国) | 米兰体育-米兰体育（中国） | 开云手机在线登陆入口 | 江南官方体育网页版 | 开云网页版 | 开云官方在线入口 | 开云电子体育 | 开云官方链接 | 江南网页版页面登录 |