RLIM Antibody

中文名称：

RLIM兔多克隆抗体
货号：

CSB-PA019748GA01HU
规格：

￥3,900
其他：

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Uniprot No.：

Q9NVW2
基因名：

RLIM
别名：

E3 ubiquitin-protein ligase RLIM antibody; LIM domain-interacting RING finger protein antibody; R-LIM antibody; Renal carcinoma antigen NY-REN-43 antibody; RING finger LIM domain-binding protein antibody; RING finger protein 12 antibody; RLIM antibody; RNF12 antibody; RNF12_HUMAN antibody
宿主：

Rabbit
反应种属：

Human,Mouse,Rat
免疫原：

Human RLIM
免疫原种属：

Homo sapiens (Human)
抗体亚型：

IgG
纯化方式：

Antigen Affinity purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
产品提供形式：

Liquid
应用范围：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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功能：

E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
基因功能参考文献：
1. Results from a study on gene expression variability markers in early-stage human embryos shows that RLIM is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
2. missense mutation in RLIM gene was identified in four males with intellectual disability from a three-generation family. PMID: 25735484
3. RNF12 is a novel positive regulator of p53 pathway and an external E3 ubiquitin ligase for MDM2 destruction. PMID: 26926424
4. Rlim is a novel regulator of Stathmin protein in a ubiquitin-dependent manner, and represents a new pathway for malignant phenotype turnover by modulating the level of Stathmin protein in human osteosarcomas. PMID: 24686088
5. hus regulated nucleocytoplasmic shuttling of RLIM/Rnf12 coordinates cellular compartments during mammary alveolar cell survival PMID: 23904271
6. TP53 does not directly bind to the RLIM promoter, it physically interacts with and prevents the binding of Sp1 to the RLIM promoter. PMID: 23650532
7. these results indicated that RLIM is an important positive regulator in TGF-beta signaling pathway and cell migration. PMID: 21945933
8. RLIM represents a new pathway for telomere maintenance by modulating the level of TRF1 at telomeres. PMID: 19164295
9. These findings provide evidence for a dose-dependent role of RNF12 in the XCI counting and initiation process. PMID: 19945382
10. Functional analysis of the Xenopus homolog PMID: 12874135
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相关疾病：

Mental retardation, X-linked 61 (MRX61)
亚细胞定位：

Nucleus.
蛋白家族：

RNF12 family
组织特异性：

Expressed in many tissues.
数据库链接：

HGNC: 13429

OMIM: 300379

KEGG: hsa:51132

STRING: 9606.ENSP00000253571

UniGene: Hs.653288

RLIM Antibody

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