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  4. Recombinant Human E3 ubiquitin-protein ligase MIB2 (MIB2), partial

Recombinant Human E3 ubiquitin-protein ligase MIB2 (MIB2), partial

  • 中文名称：
    人MIB2重组蛋白
  • 货号：
    CSB-YP839291HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人MIB2重组蛋白
  • 货号：
    CSB-EP839291HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人MIB2重组蛋白
  • 货号：
    CSB-EP839291HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人MIB2重组蛋白
  • 货号：
    CSB-BP839291HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人MIB2重组蛋白
  • 货号：
    CSB-MP839291HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MIB2
  • Uniprot No.：
    Q96AX9
  • 别名：
    MIB2; SKD; ZZANK1; E3 ubiquitin-protein ligase MIB2; EC 2.3.2.27; Mind bomb homolog 2; Novel zinc finger protein; Novelzin; Putative NF-kappa-B-activating protein 002N; RING-type E3 ubiquitin transferase MIB2; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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MIB2 antibodies

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
  • 基因功能参考文献：
    1. Missense p.V742G variant in MIB2 is associated with left ventricle hypertrabeculation/non-compaction and Menetrier-like gastropathy. PMID: 28013292
    2. Here, we report a novel interaction between CYLD and MIB2 that supports the hypothesis that the CYLD/MIB2 interaction might play a pathogenic role in human cancer. PMID: 25565632
    3. identify MIB2 as a novel component of the activated BCL10 signaling complex and a missing link in the BCL10-dependent NF-kappaB signaling pathway. PMID: 21896478
    4. Mib2 has functional similarities to Mib1, but might have distinct roles in Notch signaling as an E3 ubiquitin ligase PMID: 15824097
    5. Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is down-regulated in melanoma. PMID: 15869411
    6. skeletrophin is a novel ubiquitin ligase that targets the intracellular region of Jagged-2 and is aberrantly overexpressed in multiple myeloma cells. PMID: 15920166
    7. skeletrophin might be a novel suppressor factor for melanoma invasion PMID: 16715130
    8. Data identify Mind bomb-2 as an E3 ubiquitin ligase that interacts with and ubiquitinates the NR2B subunit of the NMDAR in mammalian cells. PMID: 17962190

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  • 亚细胞定位：
    Cytoplasm. Endosome. Note=Colocalizes with endosomal compartments.
  • 组织特异性：
    Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
  • 数据库链接：

    HGNC: 30577

    OMIM: 611141

    KEGG: hsa:142678

    STRING: 9606.ENSP00000426103

    UniGene: Hs.135805

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