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  4. Recombinant Human Cystatin-F (CST7)

Recombinant Human Cystatin-F (CST7)

  • 中文名称：
    Recombinant Human Cystatin-F(CST7)
  • 货号：
    CSB-YP006095HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Cystatin-F(CST7)
  • 货号：
    CSB-EP006095HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Cystatin-F(CST7)
  • 货号：
    CSB-EP006095HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Cystatin-F(CST7)
  • 货号：
    CSB-BP006095HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Cystatin-F(CST7)
  • 货号：
    CSB-MP006095HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CST7
  • Uniprot No.：
    O76096
  • 别名：
    CMAP; CST 7; Cst7; Cystatin 7; cystatin F (leukocystatin); Cystatin like metastasis associated protein; Cystatin-7; Cystatin-F; Cystatin-like metastasis-associated protein; Cystatin7; CystatinF; CYTF_HUMAN; dJ568C11.1; Leukocystatin
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-145
  • 氨基酸序列
    G PSPDTCSQDL NSRVKPGFPK TIKTNDPGVL QAARYSVEKF NNCTNDMFLF KESRITRALV QIVKGLKYML EVEIGRTTCK KNQHLRLDDC DFQTNHTLKQ TLSCYSEVWV VPWLQHFEVP VLRCH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system.
  • 基因功能参考文献：
    1. during monocyte to macrophage differentiation, the endosomal/lysosomal proteolytic activity can be regulated by cystatin F whose expression is under the control of transcriptional factor C/EBP alpha. PMID: 30033148
    2. Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells. PMID: 22365146
    3. Transgenic cystatin F is expressed in model mice only during demyelination; in chronic demyelination, remyelinating ability is lost. PMID: 21344476
    4. cystatin F is an intracellular cysteine peptidase inhibitor with readily regulated expression PMID: 12423348
    5. CST7 is secreted, but artificial modification of its C-terminus can induce its endocytic targeting. PMID: 15212960
    6. Cystatin F was not colocalized with cystatin C shich suggests distinct functions for these two cysteine protease inhibitors in U937 cells. PMID: 15752368
    7. analysis of reduction-dependent activation of human cystatin F PMID: 16601115
    8. A latent protease inhibitor which is itself regulated by proteolysis in the endocytic pathway. PMID: 18256700
    9. Data demonstrate the addition of N-linked sugars to an Asn-X-Cys motif in cystatin F and suggest that the mannose 6-phosphate sorting machinery is used to divert cystatin F from the secretory pathway and to mediate its uptake from extracellular pools. PMID: 19192250

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  • 亚细胞定位：
    Secreted. Cytoplasm.
  • 蛋白家族：
    Cystatin family
  • 组织特异性：
    Primarily expressed in peripheral blood cells and spleen.
  • 数据库链接：

    HGNC: 2479

    OMIM: 603253

    KEGG: hsa:8530

    STRING: 9606.ENSP00000420384

    UniGene: Hs.143212

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