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Recombinant G1/S-specific cyclin-E (cye-1), partial

  • 中文名称:
    Recombinant G1/S-specific cyclin-E(cye-1) ,partial
  • 货号:
    CSB-YP517288CXY
  • 规格:
  • 来源:
    Yeast
  • 其他:
  • 中文名称:
    Recombinant G1/S-specific cyclin-E(cye-1) ,partial
  • 货号:
    CSB-EP517288CXY
  • 规格:
  • 来源:
    E.coli
  • 其他:
  • 中文名称:
    Recombinant G1/S-specific cyclin-E(cye-1) ,partial
  • 货号:
    CSB-EP517288CXY-B
  • 规格:
  • 来源:
    E.coli
  • 共轭:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名称:
    Recombinant G1/S-specific cyclin-E(cye-1) ,partial
  • 货号:
    CSB-BP517288CXY
  • 规格:
  • 来源:
    Baculovirus
  • 其他:
  • 中文名称:
    Recombinant G1/S-specific cyclin-E(cye-1) ,partial
  • 货号:
    CSB-MP517288CXY
  • 规格:
  • 来源:
    Mammalian cell
  • 其他:

产品详情

  • 纯度:
    >85% (SDS-PAGE)
  • 基因名:
    cye-1
  • Uniprot No.:
  • 别名:
    cye-1; C37A2.4G1/S-specific cyclin-E
  • 种属:
    Caenorhabditis elegans
  • 蛋白长度:
    Partial
  • 蛋白标签:
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

产品评价

靶点详情

  • 功能:
    Essential for the control of the cell cycle at the G1/S (start) transition. In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase. During hypoderm development at early larval stages, controls syncytial fate of seam cell daughter cells. Involved in the progression of cell division in the intestinal lineage in larvae, and in particular in endoreplication, a specific growth pathway in the intestinal epithelium, required for feeding and gut development in growing larvae. By controlling the activity of translational repressor gld-1, regulates the pool of germline stem cells and the size of the mitotic zone by preventing entry into meiosis. In addition, repression of expression by gld-1 prevents mitosis re-entry in meiotic germline cells.
  • 基因功能参考文献:
    1. results suggest that the balance between the levels of CKI and cyclin E determines three distinct cell states: terminally differentiated, quiescent and uncommitted, and proliferating PMID: 17476329
    2. Notch and Prospero repress proliferation following cyclin E overexpression in bristle cell lineage. PMID: 19662164
    3. GLD-1 represses translation of CYE-1/cyclin E during meiotic prophase, which prevents germ cells from re-entering mitosis and inducing embryonic-like transcription PMID: 19758560
  • 亚细胞定位:
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
  • 蛋白家族:
    Cyclin family, Cyclin E subfamily
  • 组织特异性:
    Expressed dynamically in proliferating cells throughout development. Detectable in larval blast cells undergoing active proliferation that give rise to all tissue types, including germline, intestine, hypodermis, neurons, and muscle.
  • 数据库链接:

    KEGG: cel:CELE_C37A2.4

    STRING: 6239.C37A2.4a

    UniGene: Cel.9296