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  4. Recombinant Epstein-Barr virus Deneddylase BPLF1 (BPLF1), partial

Recombinant Epstein-Barr virus Deneddylase BPLF1 (BPLF1), partial

  • 中文名称：
    Recombinant Epstein-Barr virus Deneddylase BPLF1 (BPLF1) ,partial
  • 货号：
    CSB-YP365871EFA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Epstein-Barr virus Deneddylase BPLF1 (BPLF1) ,partial
  • 货号：
    CSB-EP365871EFA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Epstein-Barr virus Deneddylase BPLF1 (BPLF1) ,partial
  • 货号：
    CSB-BP365871EFA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Epstein-Barr virus Deneddylase BPLF1 (BPLF1) ,partial
  • 货号：
    CSB-MP365871EFA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    BPLF1
  • Uniprot No.：
    P03186
  • 别名：
    BPLF1; Large tegument protein deneddylase; EC 3.4.19.12; EC 3.4.22.-
  • 种属：
    Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

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BPLF1 Proteins

靶点详情

  • 功能：
    Large tegument protein that plays multiple roles in the viral cycle. During viral entry, remains associated with the capsid while most of the tegument is detached and participates in the capsid transport toward the host nucleus. Plays a role in the routing of the capsid at the nuclear pore complex and subsequent uncoating. Within the host nucleus, acts as a deneddylase and promotes the degradation of nuclear CRLs (cullin-RING ubiquitin ligases) and thereby stabilizes nuclear CRL substrates, while cytoplasmic CRLs remain unaffected. These modifications prevent host cell cycle S-phase progression and create a favorable environment allowing efficient viral genome replication. Participates later in the secondary envelopment of capsids. Indeed, plays a linker role for the association of the outer viral tegument to the capsids together with the inner tegument protein.
  • 基因功能参考文献：
    1. This work evaluates how EBV's BPLF1 protein and its conserved deubiquitinating activity regulate the cellular DNA repair enzyme polymerase eta and recruit it to potential sites of viral damage and replication, resulting in enhanced production of infectious virus. PMID: 28724765
    2. The results implicate BPLF1 in human B-cell transformation and tumor formation in humanized mice. PMID: 26489865
    3. we show that the conserved herpesvirus large tegument protein BPLF1, acts as a functional ubiquitin ligase and deubiquitinase in EBV-producing B cells PMID: 24586164
    4. The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity. PMID: 24672041
    5. The Epstein-Barr virus protein BPLF1, is targeted to cullin-RING ubiquitin ligases (CRLs) via the interaction of the conserved helix-2 with helix-23 of cullins, at a site involved in electrostatic interaction with CAND1. PMID: 22474075
    6. BPLF1 deubiquitinates TRAF6 to inhibit NF-kappaB signal transduction, leading to promotion of viral lytic DNA replication. PMID: 23365429

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  • 亚细胞定位：
    Virion tegument. Host cytoplasm. Host nucleus.
  • 蛋白家族：
    Herpesviridae large tegument protein family
  • 数据库链接：

    KEGG: vg:3783726

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