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  4. Recombinant Drosophila melanogaster Modifier of mdg4 (mod (mdg4)), partial

Recombinant Drosophila melanogaster Modifier of mdg4 (mod (mdg4)), partial

  • 中文名称：
    黑腹果蝇mod(mdg4)重组蛋白
  • 货号：
    CSB-YP771300DLU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    黑腹果蝇mod(mdg4)重组蛋白
  • 货号：
    CSB-EP771300DLU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    黑腹果蝇mod(mdg4)重组蛋白
  • 货号：
    CSB-EP771300DLU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    黑腹果蝇mod(mdg4)重组蛋白
  • 货号：
    CSB-BP771300DLU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    黑腹果蝇mod(mdg4)重组蛋白
  • 货号：
    CSB-MP771300DLU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    mod(mdg4)
  • Uniprot No.：
    Q86B87
  • 别名：
    mod(mdg4); bpd; doom; E(var)3-93D; CG32491Modifier of mdg4
  • 种属：
    Drosophila melanogaster (Fruit fly)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may control the nature of the repressive effect of su(Hw): in the absence of mod(mdg4) protein, su(Hw) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4), the silencing effect is unidirectional. Isoform H is specifically required to maintain the pairing of achiasmate homologs in male meiosis I which is mediated by the rDNA repeats on the achiasmate X-Y bivalents. Isoform H also plays a role in apoptotic regulatory pathways.
  • 基因功能参考文献：
    1. Mod(mdg4) directly interacts with mtACP1A and mtACP1B proteins. PMID: 27025476
    2. Results show that mod(mdg4) pre-mRNAs are alternatively spliced, and a very significant fraction of the mature mod(mdg4) mRNAs are formed by trans-splicing. PMID: 24526065
    3. The phenotypes that emerge in the context of wild-type levels of the HP1 and Mod(mdg4) proteins might be part of an adaptive response to the environment. PMID: 23636736
    4. Trans-splicing takes place between transcripts produced on two different chromosomes to produce mod(mdg4) 2.2 protein PMID: 11973303
    5. functional correlation between the large number of different isoforms and the pleiotropic mutant phenotypes of most mod(mdg4) mutations. Putative function of Mod(mdg4) proteins as chromatin modulators involved in higher order chromatin domains PMID: 12723696
    6. the absence of the Mod(mdg4) protein allows the Su(Hw) insulator to function differently PMID: 12856417
    7. Trans-splicing of the mod(mdg4) complex locus is conserved between the distantly related species Drosophila melanogaster and D. virilis. PMID: 15520256
    8. analysis of MDG4 (Gypsy) sequences in the Drosophila melanogaster genome PMID: 15846993
    9. These data suggest that the Mod(mdg4)-67.2 BTB domain confers novel activities to gypsy insulator function. PMID: 17101769
    10. A mutation in the common region of mod(mdg4), Z3-3401, that causes qualitatively similar phenotypes as the MNM-specific alleles but disrupts X-Y segregation much more drastically than autosomal segregation, is described. PMID: 17277376
    11. Mod(mdg4)devoid of the Q-rich domain supports the function of Su(Hw)-dependent insulators and efficiently binds to correct insulators on the chromosome, but does not form or enter the Su(*Hw)-marked nuclear speckles. PMID: 18369369

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 数据库链接：

    KEGG: dme:Dmel_CG32491

    STRING: 7227.FBpp0292464

    UniGene: Dm.20407

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