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  4. Recombinant Danio rerio T-box transcription factor TBX2b (tbx2b), partial

Recombinant Danio rerio T-box transcription factor TBX2b (tbx2b), partial

  • 中文名称：
    斑马鱼tbx2b重组蛋白
  • 货号：
    CSB-YP800241DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斑马鱼tbx2b重组蛋白
  • 货号：
    CSB-EP800241DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斑马鱼tbx2b重组蛋白
  • 货号：
    CSB-EP800241DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斑马鱼tbx2b重组蛋白
  • 货号：
    CSB-BP800241DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斑马鱼tbx2b重组蛋白
  • 货号：
    CSB-MP800241DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    tbx2b
  • Uniprot No.：
    Q7ZTU9
  • 别名：
    tbx2b; tbx-c; T-box transcription factor TBX2b; T-box protein 2b
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor which acts as a transcriptional repressor. May also function as a transcriptional activator. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes. Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation.
  • 基因功能参考文献：
    1. Bone morphogenetic protein signaling regulates hepatoblast-like cell differentiation into hepatocytes through tbx2b. PMID: 28599080
    2. tbx2a/b mitigate pronephros segmentation downstream of retinoic acid. PMID: 27840199
    3. propose here a rather unique role of Med10 in orchestrating cardiac valve formation by mediating Foxn4 dependent tbx2b transcription, expression of Has2 and subsequently proper development of the cardiac jelly PMID: 27343557
    4. This work establishes a novel link between tbx2b and gdf6a in determining photoreceptor fates. PMID: 24681822
    5. Genetic disruption of the transcription factor Tbx2b eliminates most of the cone subtype maximally sensitive to ultraviolet wavelengths and also perturbs the long-range organization of the cone lattice. PMID: 24465536
    6. Wnt/beta-catenin signaling is both sufficient and required for the induction of BMP4 and Tbx2b expression in the AVC PMID: 21567896
    7. In zebrafish, two tbx2 genes are functionally redundant for regulating chamber development, while each gene is required independently for development of the atrioventricular canal. PMID: 21448936
    8. results uncover an evolutionarily conserved role of Tbx2/3 transcription factors during remodeling of the heart myocardium and highlight the importance of controlling cell proliferation as a driving force of morphogenesis PMID: 17460765
    9. cellular mechanisms regulating neuronal differentiation within the retina are asymmetric about the dorsal/ventral axis, and Tbx2b mediates this process within the dorsal retina PMID: 15755805
    10. Data show that tbx2b transcripts are present during mid-gastrula before its expression is detected by whole-mount in situ hybridization. PMID: 16033799
    11. tbx2b functions to specify the correct number of parapineal cells and to regulate their asymmetric migration. PMID: 18385257
    12. Flh and Tbx2b regulate separate programs of pineal and parapineal development PMID: 18629869
    13. tbx2b in photoreceptor cell precursors promote the UV cone fate by repressing the rod differentiation pathway PMID: 19179291

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in the axial mesoderm, notably, in the notochordal precursor cells immediately before formation of the notochord and in the chordoneural hinge of the tail bud, after the notochord is formed. In addition, its expression is detected in the ventral
  • 数据库链接：

    KEGG: dre:30253

    STRING: 7955.ENSDARP00000107769

    UniGene: Dr.8233

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