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  4. Recombinant Danio rerio R-spondin-3 (rspo3)

Recombinant Danio rerio R-spondin-3 (rspo3)

  • 中文名称：
    斑马鱼rspo3重组蛋白
  • 货号：
    CSB-YP728873DIL
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    斑马鱼rspo3重组蛋白
  • 货号：
    CSB-EP728873DIL
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    斑马鱼rspo3重组蛋白
  • 货号：
    CSB-EP728873DIL-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    斑马鱼rspo3重组蛋白
  • 货号：
    CSB-BP728873DIL
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    斑马鱼rspo3重组蛋白
  • 货号：
    CSB-MP728873DIL
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    rspo3
  • Uniprot No.：
    Q5R328
  • 别名：
    rspo3; sb:cb387; zgc:162040; R-spondin-3; Cabriolet; Roof plate-specific spondin-3
  • 种属：
    Danio rerio (Zebrafish) (Brachydanio rerio)
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-317
  • 氨基酸序列
    QHHGSRHRGN KQVSGVSSQG CQGGCQTCSV YNGCLTCKPK LFIHLERDGM RQIGVCLASC PNGFYGTRSP DRNDCIKCGS ECDSCFNRNF CLRCRAGSYL HKGKCMESCP DGLVPSDTKK ECVAACPALC DLCQNSDTCT RCVPGHFLHA GQCHHVCPDE FEPNDSMECI PTVHCEVSEW SEWGTCSRSG KTCGFKWGEE TRTRKVLQNP SPMGSPCPPT SEKRECFVKK KRCKPPKGQR RGEKKKRFNL QEKVTAEARR ERKREREKET IDREESENRN KTEQRRRRDQ SRDAGTV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Activator of the canonical Wnt signaling pathway by acting as a ligand for lgr4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to lgr4-6 (lgr4, lgr5 or lgr6), lgr4-6 associate with phosphorylated lrp6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Acts both in the canonical. Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway. Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells. Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3.
  • 基因功能参考文献：
    1. Rspo3 regulates dorsoventral and anteroposterior patterning in zebrafish embryos by negatively regulating the zygotic Wnt/beta-catenin signaling. PMID: 24918770
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    R-spondin family
  • 数据库链接：

    KEGG: dre:100007702

    STRING: 7955.ENSDARP00000058577

    UniGene: Dr.75336

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