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  4. Recombinant Bovine Thrombospondin-1 (THBS1), partial

Recombinant Bovine Thrombospondin-1 (THBS1), partial

  • 中文名称：
    牛THBS1重组蛋白
  • 货号：
    CSB-YP631701BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛THBS1重组蛋白
  • 货号：
    CSB-EP631701BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛THBS1重组蛋白
  • 货号：
    CSB-EP631701BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛THBS1重组蛋白
  • 货号：
    CSB-BP631701BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛THBS1重组蛋白
  • 货号：
    CSB-MP631701BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    THBS1
  • Uniprot No.：
    Q28178
  • 别名：
    THBS1; TSP-1; TSP1; Thrombospondin-1; Glycoprotein G
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors.
  • 基因功能参考文献：
    1. temporal expression and localization pattern of the thrombospondins and their specific receptors in the antral follicles and corpora lutea during the different physiological phases of the estrous cycle and induced luteolysis appear to be compatible with their inhibitory role in the control of ovarian angiogenesis PMID: 27396384
    2. Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2, up-regulates expression of FGF2 (fibroblast growth factor 2). PMID: 25061096
    3. role in inducing vascular smooth muscle cell chemotaxis PMID: 12761883
    4. thrombospondin has a role in regulating the migratory phenotype of endothelial cells and fibroblasts PMID: 12808019
    5. Thrombospondin has a role in inducing RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly PMID: 15371459
    6. Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF was inversely expressed, with expression increasing as follicles developed. PMID: 15616224
    7. Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin-like growth factor PMID: 15927849
    8. The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications PMID: 18096704
    9. The novel finding that TSP-1-induced migration is dependent on the CD44 receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA). PMID: 19887196

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  • 亚细胞定位：
    Secreted. Cell surface. Secreted, extracellular space, extracellular matrix. Endoplasmic reticulum. Sarcoplasmic reticulum.
  • 蛋白家族：
    Thrombospondin family
  • 组织特异性：
    Odontoblasts.
  • 数据库链接：

    KEGG: bta:281530

    STRING: 9913.ENSBTAP00000002600

    UniGene: Bt.109568

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