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  4. Recombinant Bovine Signal transducer and activator of transcription 5A (STAT5A), partial

Recombinant Bovine Signal transducer and activator of transcription 5A (STAT5A), partial

  • 中文名称：
    牛STAT5A重组蛋白
  • 货号：
    CSB-YP022814BO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    牛STAT5A重组蛋白
  • 货号：
    CSB-EP022814BO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    牛STAT5A重组蛋白
  • 货号：
    CSB-EP022814BO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    牛STAT5A重组蛋白
  • 货号：
    CSB-BP022814BO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    牛STAT5A重组蛋白
  • 货号：
    CSB-MP022814BO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    STAT5A
  • Uniprot No.：
    Q95115
  • 别名：
    STAT5A; MGF; Signal transducer and activator of transcription 5A; Mammary gland factor
  • 种属：
    Bos taurus (Bovine)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
  • 基因功能参考文献：
    1. Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 and mTOR signaling pathways. PMID: 26108540
    2. There was no association between the genotypes of GH and IGF-IS and fertility of Holstein cows raised in semiextensive or intensive regimes, while the STAT5 ABstEII polymorphism was associated with calving-first heat interval in Holstein cows raised in the intensive system. PMID: 27865414
    3. Milk production traits were analyzed for each animal in the first, second, third, and fourth lactation. No genetic variability was found at STAT5A/AvaI locus. At STAT5A/MslI locus, the frequencies of T and C alleles were 0.875 and 0.125, respectively. Significant differences between genotypes were found PMID: 27885437
    4. Results indicate that SNPs in STAT5A and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity. PMID: 25205126
    5. The embryonic STAT5A gene is primarily activated by maternal gene products and the most abundant STAT5A expression occurred at the 2-cell stage blastocysts. PMID: 23981721
    6. INVESTIGATION OF STAT5A, FSHR AND LHR GENE POLYMORPHISMS IN TURKISH INDIGENOUS CATTLE BREEDS PMID: 26845856
    7. The Stat5a gene is associated with an increase in lactation of mammary gland epithelial cells. PMID: 23054437
    8. STAT5A/AvaI polymorphism seems to be a promising indirect marker to improve milk production traits in cattle. PMID: 21390501
    9. Associations between reproduction and milk traits, and polymorphisms at the STAT5A and FGF2 gene loci, were found with STAT5A polymorphism for age at first calving (suggestive effect; P =0.077) and lactation milk yield (significant effect; P<0.05). PMID: 21310447
    10. Base sequence variation in STAT5A-noncoding region was studied. PMID: 16187168
    11. The association of fertilization rate with STAT5A polymorphisms was evaluated in ocytes. Associations were found for 6 and 2 SNP. 5 SNP showed associations with both embryonic survival and fertilization rate compared with 1 SNP. PMID: 18218766
    12. STAT5A affects embryonic survival in a manner influenced by developmental stage and allele parent of origin. PMID: 19284551
    13. Although more studies are needed to better clarify the role of this SNP on production traits, STAT5A/AvaI polymorphism appears to be a promising indirect marker to improve milk production traits in cattle. PMID: 19638264

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Transcription factor STAT family
  • 数据库链接：

    KEGG: bta:282375

    STRING: 9913.ENSBTAP00000034715

    UniGene: Bt.4641

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