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  4. LILRA4 Recombinant Monoclonal Antibody

LILRA4 Recombinant Monoclonal Antibody

说明书
  • 中文名称：
    LILRA4 Recombinant Monoclonal Antibody
  • 货号：
    CSB-RA012936MA1HU
  • 规格：
    ￥1320
  • 图片：
    • Western Blot Positive WB detected in:Hela whole cell lysate (20µg), HpeG2 whole cell lysate (20µg), Jurkat whole cell lysate (20µg), K562 whole cell lysate (20µg) All lanes: LILRA4 antibody at 1:1000 Secondary Goat polyclonal to human IgG at 1/40000 dilution Predicted band size:55.18, 47.81 kDa Observed band size:50 kDa Exposure time:20s
    • IHC image of CSB-RA012936MA1HU diluted at 1:100 and staining in paraffin-embedded human skin tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品描述：
    CSB-RA012936MA1HU LILRA4重组单克隆抗体是针对人白细胞免疫球蛋白样受体A4（LILRA4）开发的高特异性科研工具。该抗体采用重组技术制备，可精准识别LILRA4蛋白，该靶标作为免疫调节受体家族成员，在髓系细胞中特异性表达，参与调控天然免疫应答及炎症反应，与自身免疫性疾病、病毒感染等病理过程密切相关。经严格验证，本产品在Western Blot实验中可识别重组表达及天然LILRA4蛋白，在1:500-1:2000稀释范围内呈现清晰的特异性条带；免疫组化应用显示其在1:50-1:200浓度下能有效定位石蜡包埋组织中LILRA4的细胞膜/胞质分布，同时适用于ELISA检测体系。该抗体具备优异的批间一致性，适用于探索LILRA4在免疫细胞功能调控、疾病相关信号通路及肿瘤微环境中的作用机制，为免疫学研究、炎症性疾病模型构建及靶向治疗策略开发提供可靠试剂支持，建议配合同源重组蛋白用于实验体系验证。
  • Uniprot No.：
    P59901
  • 基因名：
    LILRA4
  • 别名：
    CD85 antigen-like family member G antibody; CD85g antibody; ILT-7 antibody; ILT7 antibody; Immunoglobulin like transcript 7 antibody; Immunoglobulin-like transcript 7 antibody; Leukocyte immunoglobulin-like receptor subfamily A member 4 antibody; LILRA4 antibody; LIRA4_HUMAN antibody; MGC129597 antibody; MGC129598 antibody
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human LILRA4 protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Monoclonal
  • 抗体亚型：
    hIgG1
  • 纯化方式：
    Affinity-chromatography
  • 克隆号：
    24F6
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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LILRA4 antibodies

LILRA4 Proteins

靶点详情

  • 功能：
    Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells.
  • 基因功能参考文献：
    1. Crosslinked ILT7 favours the differentiation of immature plasmacytoid dendritic cells into antigen-presenting cells rather than IPC. PMID: 24586760
    2. ILT7 may exert its immunomodulatory activity only on immature circulating plasmacytoid dendritic cells (pDCs), providing a basic homeostatic mechanism rather than negative feedback control on activated pDCs. PMID: 23401591
    3. Intracellular expression of the TCL1 as well as membrane and intracellular expression of ILT7 in plasmacytoid dendritic cell leukemia (pDCL) samples and 61 non-pDC acute leukemia samples, were tested. PMID: 22674796
    4. the expression of immunoglobulin-like transcript 7, in plasmacytoid dendritic cells PMID: 12384430
    5. ILT7 protein associates with the signal adapter protein Fc epsilonRI gamma to form a receptor complex in dendritic cells. PMID: 16735691
    6. key regulator of human pDC function and interferon type I production. PMID: 18048391
    7. Data show that BST2 directly binds to purified ILT7, initiates signaling via the ILT7-FcepsilonRIgamma complex, and regulates TLR7/9 responses in plasmacytoid dendritic cells. PMID: 19564354

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells.
  • 数据库链接：

    HGNC: 15503

    OMIM: 607517

    KEGG: hsa:23547

    STRING: 9606.ENSP00000291759

    UniGene: Hs.406708

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