PLCH1 Antibody

产品详情

Uniprot No.：

Q4KWH8
基因名：

PLCH1
别名：

1-phosphatidylinositol 4 antibody; 1-phosphatidylinositol-4 antibody; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase eta-1 antibody; 5-bisphosphate phosphodiesterase eta-1 antibody; DKFZp434C1372 antibody; KIAA1069 antibody; MGC117152 antibody; Phosphoinositide phospholipase C-eta-1 antibody; Phospholipase C-eta-1 antibody; Phospholipase C-like protein 3 antibody; PLC-eta-1 antibody; PLC-L3 antibody; PLCeta1 antibody; Plch1 antibody; PLCH1_HUMAN antibody; PLCL3 antibody
宿主：

Rabbit
反应种属：

Human,Mouse,Rat
免疫原：

Human PLCH1
免疫原种属：

Homo sapiens (Human)
抗体亚型：

IgG
纯化方式：

Antigen Affinity purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
产品提供形式：

Liquid
应用范围：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes.
基因功能参考文献：
1. High fertilization (56.06%) and pregnancy (41.7%) rates accomplished in this study following ICSI-AOA indicated that expression profiles of PLCzeta, PAWP, and TR-KIT were low in globozoospermic individuals PMID: 27089467
2. A molecular model of the PLCeta2 EF-hand domain, constructed based upon the structure of calmodulin, suggested both EF-loops may participate in Ca(2+) -binding. PMID: 24123053
3. The PLCH1 rs181696 single-nucleotide polymorphism was strongly associated with an increased risk of squamous cell carcinoma. PMID: 22658813
4. molecular cloning of PLC-eta1 and PLC-eta2 PMID: 15583837
5. The identification of a novel PLC isoform in the brains of human and mouse, named PLC-eta, which contains the conserved pleckstrin homology domain, X and Y domains for catalytic activity and the C2 domain. PMID: 15702972
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亚细胞定位：

Cytoplasm. Membrane.
组织特异性：

Expressed in brain and to a lower extent in lung. In brain, it is found in cerebrum, cerebellum and spinal cord.
数据库链接：

HGNC: 29185

OMIM: 612835

KEGG: hsa:23007

STRING: 9606.ENSP00000345988

UniGene: Hs.567423