NUP93 Antibody, FITC conjugated

产品详情

产品名称：

Rabbit anti-Homo sapiens (Human) NUP93 Polyclonal antibody
Uniprot No.：

Q8N1F7
基因名：

NUP93
别名：

NUP93 antibody; KIAA0095Nuclear pore complex protein Nup93 antibody; 93 kDa nucleoporin antibody; Nucleoporin Nup93 antibody
宿主：

Rabbit
反应种属：

Human
免疫原：

Recombinant Human Nuclear pore complex protein Nup93 protein (14-180AA)
免疫原种属：

Homo sapiens (Human)
标记方式：

FITC
克隆类型：

Polyclonal
抗体亚型：

IgG
纯化方式：

>95%, Protein G purified
浓度：

It differs from different batches. Please contact us to confirm it.
保存缓冲液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
产品提供形式：

Liquid
储存条件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
货期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling.
基因功能参考文献：
1. we show that knockdown of Nup188 or its binding partner Nup93 leads to a loss of cilia during embryonic development while leaving NPC function largely intact. Many data, including the localization of endogenous Nup188/93 at cilia bases, support their direct role at cilia. Super-resolution imaging of Nup188 shows two barrel-like structures PMID: 27593162
2. NUP93 and exportin 5 interact with the signaling protein SMAD4 and that NUP93 mutations abrogated interaction with SMAD4 PMID: 26878725
3. Caspases target only Nup93 and Nup96 within the core structure of the nuclear pore complex PMID: 16286466
相关疾病：

Nephrotic syndrome 12 (NPHS12)
亚细胞定位：

Nucleus membrane; Peripheral membrane protein. Nucleus, nuclear pore complex. Nucleus envelope.
蛋白家族：

Nucleoporin interacting component (NIC) family
数据库链接：

HGNC: 28958

OMIM: 614351

KEGG: hsa:9688

STRING: 9606.ENSP00000310668

UniGene: Hs.276878