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  4. CHRDL1 Antibody

CHRDL1 Antibody

说明书
  • 中文名称：
    CHRDL1兔多克隆抗体
  • 货号：
    CSB-PA866283LA01HU
  • 规格：
    ￥440
  • 图片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate
      All lanes: CHRDL1 antibody at 5.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 52, 44, 53 kDa
      Observed band size: 52 kDa
    • IHC image of CSB-PA866283LA01HU diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CHRDL1 Polyclonal antibody
  • Uniprot No.：
    Q9BU40
  • 基因名：
    CHRDL1
  • 别名：
    CHL antibody; chordin like 1 antibody; Chordin-like protein 1 antibody; CHRDL1 antibody; CRDL1_HUMAN antibody; dA141H5.1 antibody; neuralin 1 antibody; Neuralin-1 antibody; Neurogenesin-1 antibody; NRLN1 antibody; Ventroptin antibody; VOPT antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Chordin-like protein 1 protein (92-237AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CHRDL1 Antibody (CSB-PA866283LA01HU)，的标记方式是Non-conjugated。对于CHRDL1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA866283LB01HU CHRDL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA866283LC01HU CHRDL1 Antibody, FITC conjugated
    Biotin CSB-PA866283LD01HU CHRDL1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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靶点详情

  • 功能：
    Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation. May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.
  • 基因功能参考文献：
    1. Finally, in vivo experiments confirmed that CHRDL1 acted as a tumor suppressor gene in suppressing tumor growth and metastasis PMID: 28423564
    2. Results show that Chrdl1 expression is upregulated in numerous breast cancer cells following TGF-beta stimulation and demonstrated that Chrdl1 acts as an inhibitor of BMP4-induced migration and invasion. PMID: 26976638
    3. These studies have identified and validated new factors enriched in juvenile chondrocytes as compared to adult chondrocytes including secreted extracellular matrix factors chordin-like 1 (CHRDL1) and microfibrillar-associated protein 4 (MFAP4). PMID: 26955889
    4. We provide the initial confirmation that X-linked megalocornea is associated with mutations in the CHRDL1 gene. PMID: 24073597
    5. CHRDL1 plays a key role in cornea homeostasis as evidenced by disease causing mutations in X-linked megalocornea. PMID: 25712132
    6. The detection of mutations in the CHRDL1 gene is useful for differential diagnosis with different forms of megalocornea. PMID: 26020825
    7. Novel CHRDL1 mutations in ten families with X-linked megalocornea, are reported. PMID: 25093588
    8. CHRDL1 is expressed in the developing human cornea and anterior segment in addition to the retina. PMID: 22284829
    9. Hypoxia-induced upregulation of CHL-1 alters the homeostatic balance between BMP-4 and VEGF to synergize with VEGF in driving retinal angiogenesis. PMID: 18587495
    10. reports the cloning of chick ventroptin and its importance in topographic retinotectal projection PMID: 11441185

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  • 相关疾病：
    Megalocornea 1, X-linked (MGC1)
  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes.
  • 数据库链接：

    HGNC: 29861

    OMIM: 300350

    KEGG: hsa:91851

    STRING: 9606.ENSP00000361112

    UniGene: Hs.496587

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