Recombinant Human Claudin-9 (CLDN9), partial-Detergent (Active)

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货号：

CSB-MP005511HU1-D
规格：
图片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 at 2 μg/ml on an Nickel Coated plate can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU). The EC₅₀ is 2.812-3.524 ng/mL. Biological Activity Assay
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纯度：

/
内毒素：

Less than 1.0 EU/ug as determined by LAL method.
生物活性：

Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 at 2 μg/ml on an Nickel Coated plate can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU). The EC50 is 2.812-3.524 ng/mL.
基因名：

CLDN9
Uniprot No.：

O95484
别名：

Claudin-9; CLDN9
种属：

Homo sapiens (Human)
蛋白长度：

Partial
来源：

Mammalian cell
分子量：

27.3 kDa
表达区域：

2-217aa
氨基酸序列

ASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV
蛋白标签：

N-terminal 10xHis-tagged and C-terminal Twin-Strep-tagged
产品提供形式：

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
缓冲液：

50 mM HEPES，0.15 M NaCl， 0.05% DDM，0.01% CHS，pH7.5
复溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
储存条件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保质期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
货期：

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
注意事项：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

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功能：

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
基因功能参考文献：
1. CLDN9 may be an important biomarker for invasive pituitary oncocytomas. PMID: 25281028
2. Claudins 6, 7, and 9 expressions are closely related to gastric carcinogenesis. PMID: 19960275
3. Mouse studies suggest that claudin-9 deficiency may cause hearing loss not only in mice but also in humans. PMID: 19696885
4. Residues N38 and V45 in the first extracellular loop (EL1) of CLDN9 are necessary for HCV entry. PMID: 17804490
5. CLDN9, clustered with CLDN6 at human chromosome 16p13.3, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707
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亚细胞定位：

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
蛋白家族：

Claudin family
组织特异性：

Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
数据库链接：

HGNC: 2051

OMIM: 615799

KEGG: hsa:9080

STRING: 9606.ENSP00000398017

UniGene: Hs.296949

Recombinant Human Claudin-9 (CLDN9), partial-Detergent (Active)

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