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  4. IL1F10 Monoclonal Antibody

IL1F10 Monoclonal Antibody

说明书
  • 中文名称：
    IL1F10鼠单克隆抗体
  • 货号：
    CSB-MA8378691A0m
  • 规格：
    ￥1320
  • 图片：
    • Immunohistochemical of paraffin-embedded Human Colon cancer tissue using CSB-MA8378691A0m at dilution of 1:200.
    • Immunohistochemical of paraffin-embedded Human live cancer tissue using CSB-MA8378691A0m at dilution of 1:200.
    • Immunohistochemical of paraffin-embedded Human spleen tissue using CSB-MA8378691A0m at dilution of 1:200.
  • 其他：

产品详情

  • 产品描述：
    IL1F10单克隆抗体（CUSABIO货号：CSB-MA8378691A0m）是针对白细胞介素1家族成员IL-1F10研发的高特异性科研试剂，适用于人类样本的ELISA检测及免疫组化实验。IL-1F10作为新型细胞因子，在调节炎症反应、免疫应答及组织修复等过程中发挥重要作用，其表达水平与多种病理生理过程相关，是免疫调控机制研究的关键靶点之一。本产品采用杂交瘤技术制备，经严格验证可特异性识别天然构象的IL-1F10蛋白，适用于精准检测体外培养细胞、组织切片等样本中的目标蛋白定位与表达量分析。科研人员可通过该抗体在炎症性疾病机制研究、药物靶点筛选及信号通路探索等方向开展实验，尤其在探索IL-1F10与其他细胞因子相互作用、基因表达调控网络等领域具有重要应用价值。该产品提供即用型稳定配方，实验重复性好，适用于多种蛋白检测平台，为免疫学、分子生物学及转化医学研究提供可靠工具。
  • 产品名称：
    mouse anti-Homo sapiens (Human) IL1F10 monoclonal antibody
  • Uniprot No.：
    Q8WWZ1
  • 基因名：
    IL1F10
  • 别名：
    family of interleukin 1-theta antibody; FIL1 theta antibody; FIL1T antibody; FKSG75 antibody; IL 38 antibody; IL-1 theta antibody; IL-1F10 (canonical form IL-1F10a) antibody; IL-1F10 antibody; IL-1HY2 antibody; IL1 theta antibody; IL1F10 antibody; IL1FA_HUMAN antibody; IL1HY2 antibody; Interleukin 1 family member 10 (theta) antibody; Interleukin 1 receptor antagonist FKSG75 antibody; Interleukin 1 receptor antagonist homolog 2 antibody; Interleukin 1 receptor antagonist like FIL1 theta antibody; Interleukin-1 family member 10 antibody; Interleukin-1 HY2 antibody; Interleukin-1 theta antibody; interleukin-38 antibody
  • 宿主：
    mouse
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human IL1F10 protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    monoclonal
  • 抗体亚型：
    IgG1
  • 纯化方式：
    >95%,protein G purifed
  • 克隆号：
    2A2B3
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:500
  • Protocols：
    ELISA Protocol
    Immunohistochemistry (IHC) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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IL1F10 antibodies

IL1F10 Proteins

IL1F10 ELISA kits

靶点详情

  • 功能：
    Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
  • 基因功能参考文献：
    1. The serum level of IL-38 in the children in the acute phase of Kawasaki disease was significantly lower than that in the healthy control group PMID: 30022755
    2. IL-38 may play an important role in acute and/or chronic inflammation in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis. PMID: 28942884
    3. IL-38 may exert its anti-inflammatory effects by decreasing the production of proinflammatory cytokines by macrophages and synovial fibroblasts. PMID: 28288964
    4. this clinical study demonstrates the elevation of anti-inflammatory cytokine IL-38 and the decrement of CD4+CD25highFoxP3+ and CD4+CD25highCD127- Treg in childhood asthma. The negative correlation of IL-38 and Treg lymphocytes may imply a negative feedback of the two anti-inflammatory factors in asthma. PMID: 27438823
    5. this study shows that in vivo expression of human IL-38 in mice has hepatoprotective effects against Con A-induced liver injury by inhibition of inflammatory cytokine production PMID: 27723569
    6. Higher serum IL-38 levels before treatment indicate a greater probability of viral response to telbivudine treatment in chronic hepatitis B. PMID: 27182162
    7. results indicate that circulating IL-38 is a potentially novel biomarker for patients with ST-segment elevation myocardial infarction PMID: 26819499
    8. Data suggest that IL-38 may be protective in SLE. A strong association between IL-38 and SLE severity suggests that IL-38 expression is driven by processes linked to SLE pathogenesis. PMID: 26314375
    9. rs6759676, closest gene locus IL1F10 is associated with increased circulating levels of IL-1 receptor antagonist, a protective factor in development of insulin resistance. PMID: 24969107
    10. The IL1A locus was strongly associated with alkylosing spondyloarthritis phenotype, whereas IL1F10 was associated with non-alkylosing spondyloarthritis. PMID: 22312160
    11. These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422

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  • 亚细胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    IL-1 family
  • 组织特异性：
    Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
  • 数据库链接：

    HGNC: 15552

    OMIM: 615296

    KEGG: hsa:84639

    STRING: 9606.ENSP00000341794

    UniGene: Hs.306974

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