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  4. Human Interleukin-1 family member 10(IL1F10) ELISA kit

Human Interleukin-1 family member 10(IL1F10) ELISA kit

文献引用 (3) 说明书下载
  • 中文名称：
    人白介素1家族成员10(IL1F10)酶联免疫试剂盒
  • 货号：
    CSB-EL011615HU
  • 规格：
    96T/48T
  • 价格：
    ￥3600/￥2500
  • 其他：
CUSABIO Wins 2024 Bioz Rapid Star™ Award in the ELISA category

产品详情

  • 产品描述：
    CUSABIO人白介素1家族成员10（IL1F10）酶联免疫检测试剂盒（货号：CSB-EL011615HU），采用双抗体夹心法定量检测血清、血浆及组织匀浆样本中的IL1F10蛋白浓度。IL1F10是白介素1细胞因子家族成员之一，参与调控炎症反应和免疫应答，其表达水平与自身免疫性疾病、感染性疾病及肿瘤微环境等病理过程密切相关。试剂盒检测范围为31.25 pg/mL至2000 pg/mL，可精准识别低丰度目标蛋白，适用于基础科研中探索IL1F10在炎症相关疾病模型中的作用机制、评估实验动物或细胞模型的蛋白表达动态变化，以及筛选调控该因子的药物或化合物。该试剂盒通过预包被高特异性捕获抗体和标记检测抗体的协同作用，结合显色反应实现目标蛋白的定量分析，操作流程标准化，可在常规实验室条件下完成检测。科研人员可通过本产品分析不同处理条件下生物样本（如炎症模型血清、肿瘤组织匀浆或免疫细胞培养上清）中IL1F10的表达水平，为免疫调节研究及疾病机理探索提供可靠数据支持。
  • 别名：
    family of interleukin 1-theta ELISA Kit; FIL1 theta ELISA Kit; FIL1T ELISA Kit; FKSG75 ELISA Kit; IL 38 ELISA Kit; IL-1 theta ELISA Kit; IL-1F10 (canonical form IL-1F10a) ELISA Kit; IL-1F10 ELISA Kit; IL-1HY2 ELISA Kit; IL1 theta ELISA Kit; IL1F10 ELISA Kit; IL1FA_HUMAN ELISA Kit; IL1HY2 ELISA Kit; Interleukin 1 family member 10 (theta) ELISA Kit; Interleukin 1 receptor antagonist FKSG75 ELISA Kit; Interleukin 1 receptor antagonist homolog 2 ELISA Kit; Interleukin 1 receptor antagonist like FIL1 theta ELISA Kit; Interleukin-1 family member 10 ELISA Kit; Interleukin-1 HY2 ELISA Kit; Interleukin-1 theta ELISA Kit; interleukin-38 ELISA Kit
  • 缩写：
    IL1F10
  • Uniprot No.：
  • 种属：
    Homo sapiens (Human)
  • 样本类型：
    serum, plasma, tissue homogenates
  • 检测范围：
    31.25 pg/mL-2000 pg/mL
  • 灵敏度：
    7.81 pg/mL
  • 反应时间：
    1-5h
  • 样本体积：
    50-100ul
  • 检测波长：
    450 nm
  • 研究领域：
    Immunology
  • 测定原理：
    quantitative
  • 测定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 线性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human IL1F10 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %97
    Range %92-104
    1:2Average %84
    Range %80-88
    1:4Average %105
    Range %100-113
    1:8Average %95
    Range %90-100
  • 回收率：
    The recovery of human IL1F10 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8880-92
    EDTA plasma (n=4)9490-99
  • 标准曲线：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1OD2AverageCorrected
    20002.070 2.217 2.144 2.044
    10001.393 1.321 1.357 1.257
    5000.756 0.809 0.783 0.683
    2500.421 0.445 0.433 0.333
    1250.267 0.254 0.261 0.161
    62.50.196 0.183 0.190 0.090
    31.250.151 0.154 0.153 0.053
    00.103 0.096 0.100
  • 数据处理：
    ELISA操作视频及标曲绘制软件下载
  • 货期：
    3-5 working days

引用文献

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IL1F10 antibodies

IL1F10 Proteins

靶点详情

  • 功能：
    Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.
  • 基因功能参考文献：
    1. The serum level of IL-38 in the children in the acute phase of Kawasaki disease was significantly lower than that in the healthy control group PMID: 30022755
    2. IL-38 may play an important role in acute and/or chronic inflammation in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis. PMID: 28942884
    3. IL-38 may exert its anti-inflammatory effects by decreasing the production of proinflammatory cytokines by macrophages and synovial fibroblasts. PMID: 28288964
    4. this clinical study demonstrates the elevation of anti-inflammatory cytokine IL-38 and the decrement of CD4+CD25highFoxP3+ and CD4+CD25highCD127- Treg in childhood asthma. The negative correlation of IL-38 and Treg lymphocytes may imply a negative feedback of the two anti-inflammatory factors in asthma. PMID: 27438823
    5. this study shows that in vivo expression of human IL-38 in mice has hepatoprotective effects against Con A-induced liver injury by inhibition of inflammatory cytokine production PMID: 27723569
    6. Higher serum IL-38 levels before treatment indicate a greater probability of viral response to telbivudine treatment in chronic hepatitis B. PMID: 27182162
    7. results indicate that circulating IL-38 is a potentially novel biomarker for patients with ST-segment elevation myocardial infarction PMID: 26819499
    8. Data suggest that IL-38 may be protective in SLE. A strong association between IL-38 and SLE severity suggests that IL-38 expression is driven by processes linked to SLE pathogenesis. PMID: 26314375
    9. rs6759676, closest gene locus IL1F10 is associated with increased circulating levels of IL-1 receptor antagonist, a protective factor in development of insulin resistance. PMID: 24969107
    10. The IL1A locus was strongly associated with alkylosing spondyloarthritis phenotype, whereas IL1F10 was associated with non-alkylosing spondyloarthritis. PMID: 22312160
    11. These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422

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  • 亚细胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    IL-1 family
  • 组织特异性：
    Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
  • 数据库链接：

    HGNC: 15552

    OMIM: 615296

    KEGG: hsa:84639

    STRING: 9606.ENSP00000341794

    UniGene: Hs.306974

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