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  4. HAO1 Monoclonal Antibody

HAO1 Monoclonal Antibody

说明书
  • 中文名称：
    HAO1鼠单克隆抗体
  • 货号：
    CSB-MA080172
  • 规格：
    ￥1090
  • 图片：
    • Western blot analysis of 1) Mouse Liver Tissue, 2) Rat Liver Tissue using HAO1 Monoclonal Antibody.
  • 其他：

产品详情

  • 产品描述：
    HAO1 Monoclonal Antibody（CUSABIO货号：CSB-MA080172）是针对羟基酸氧化酶1（HAO1）研发的高特异性科研抗体，适用于小鼠和大鼠样本的ELISA及Western Blot检测。该抗体采用全长人源重组蛋白作为免疫原制备，具有明确的靶向性，可精准识别HAO1蛋白在代谢通路中的表达变化。HAO1是过氧化物酶体关键酶，参与脂肪酸α氧化及电子传递过程，对研究肝脏代谢、能量稳态及遗传性代谢疾病机制具有重要科研价值。产品经严格验证，可稳定应用于细胞裂解液或组织提取物中目标蛋白的定性及半定量分析，为探索脂质代谢调控、氧化应激反应等基础研究提供可靠工具。本产品适用于生物医学领域实验室的分子机制研究、疾病模型构建及药物靶点筛选等场景，不涉及临床应用。储存时建议分装后置于-20℃环境以保持长期活性，避免反复冻融。
  • Uniprot No.：
    Q9UJM8
  • 基因名：
    HAO1
  • 别名：
    (S) 2 hydroxy acid oxidase antibody; Glycolate oxidase antibody; GOX antibody; GOX1 antibody; HAO1 antibody; HAOX1 antibody; HAOX1_HUMAN antibody; Hydroxyacid oxidase 1 antibody; MGC142225 antibody; MGC142227 antibody; OTTHUMP00000030231 antibody
  • 宿主：
    Mouse
  • 反应种属：
    Mouse,Rat
  • 免疫原：
    Recombinant Protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 克隆号：
    10D9
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
    ELISA Protocol
    Western Blotting (WB) Protocol
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

产品评价

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靶点详情

  • 功能：
    Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
  • 基因功能参考文献：
    1. The study presents the first spectroscopic evidence of the formation of an intermediate with absorbance features resembling those of a flavosemiquinone in the oxidative half-reaction of glycolate oxidase. PMID: 21141873
    2. The inhibitor heteroatoms interact with five active-site residues that have been implicated in catalysis in homologous flavodehydrogenases of L-2-hydroxy acids. In addition, the chlorophenyl substituent is surrounded by nonconserved hydrophobic residues. PMID: 20054120
    3. These inhibitions suggest that glycolate binds to the active site of the reduced enzyme, and that DCIP also has affinity for the oxidized enzyme. PMID: 17669354
    4. Active site and loop 4 movements within human glycolate oxidase. PMID: 18215067
  • 亚细胞定位：
    Peroxisome.
  • 蛋白家族：
    FMN-dependent alpha-hydroxy acid dehydrogenase family
  • 组织特异性：
    Liver.
  • 数据库链接：

    HGNC: 4809

    OMIM: 605023

    KEGG: hsa:54363

    STRING: 9606.ENSP00000368066

    UniGene: Hs.193640

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