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中文名称：小鼠巨噬细胞炎性蛋白1β(MIP-1β/CCL4)酶联免疫试剂盒
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货号：CSB-E04665m
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规格：96T/48T
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价格：￥3200/￥2500
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其他：
产品详情
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产品描述：CUSABIO小鼠巨噬细胞炎性蛋白1β（MIP-1β/CCL4）酶联免疫检测试剂盒（货号：CSB-E04665m），基于双抗体夹心法原理设计，可对血清、血浆及组织匀浆样本中的MIP-1β/CCL4进行定量分析，检测灵敏度为12.5 pg/mL，线性范围为12.5-800 pg/mL。MIP-1β/CCL4属于CC趋化因子家族成员，主要由活化的T细胞和巨噬细胞分泌，通过结合CCR5等受体参与炎症反应调控，在免疫细胞趋化、感染性疾病及自身免疫病理过程中发挥重要作用。CUSABIO试剂盒采用特异性抗体对目标蛋白进行捕获与检测，操作流程标准化，适用于科研领域中对小鼠模型炎症相关机制的研究，例如在感染性疾病模型、自身免疫疾病模型或免疫调节实验中定量分析MIP-1β/CCL4的表达动态，亦可应用于药物开发或免疫干预研究中评估该趋化因子的水平变化。实验支持多种生物样本类型检测，为探索炎症微环境及免疫调控网络提供可靠工具。
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别名：Ccl4 ELISA Kit; Mip1b ELISA Kit; Scya4 ELISA Kit; C-C motif chemokine 4 ELISA Kit; Immune activation protein 2 ELISA Kit; ACT-2 ELISA Kit; ACT2 ELISA Kit; Macrophage inflammatory protein 1-beta ELISA Kit; MIP-1-beta ELISA Kit; Protein H400 ELISA Kit; SIS-gamma ELISA Kit; Small-inducible cytokine A4 ELISA Kit
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缩写：
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Uniprot No.：
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种属：Mus musculus (Mouse)
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样本类型：serum, plasma, tissue homogenates
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检测范围：12.5 pg/mL-800 pg/mL
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灵敏度：3.12 pg/mL
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反应时间：1-5h
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样本体积：50-100ul
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检测波长：450 nm
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研究领域：Immunology
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测定原理：quantitative
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测定方法：Sandwich
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精密度：
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线性度：
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回收率：
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标准曲线：
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数据处理：
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货期：3-5 working days
引用文献
- Hepatocyte-specific deficiency of Nrf2 exacerbates carbon tetrachlorideinduced liver fibrosis via aggravated hepatocyte injury and subsequent inflammatory and fibrogenic responses Hang Lyu,Free Radical Biology and Medicine,2020
- HMBOX1 in hepatocytes attenuates LPS/D-GalN-induced liver injury by inhibiting macrophage infiltration and activation HengliZhao.et al,Molecular Immunology,2018
- Autoimmune-prone NOD mice help reveal a new genetic locus for reducing pulmonary disease caused by Mycoplasma pulmonis Wawegama NK.et al,Infect Immun,2017
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靶点详情
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功能：Monokine with inflammatory and chemokinetic properties.
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基因功能参考文献：
- CCL4-CCR5 axis can contribute to breast cancer metastasis to bone by mediating the interaction between cancer cells and fibroblasts in bone cavity. PMID: 27177471
- YY1 regulates lung CCL4 transcription in pulmonary tuberculosis. PMID: 26786659
- Ccl4 mRNAs increased within 5 h after injury in mouse cortical slices. PMID: 25895671
- CCL4 and CCL5 expression was higher in livers of infected WSX-1(-/-) mice than infected WT mice, and hepatic CD4 T cells from WSX-1(-/-) mice expressed higher levels of CCR5 than cells from WT mice PMID: 24244314
- CCL4 upregulation was associated with increased Snail expression and downregulation of p53/PTEN in high-grade PIN and prostate cancer PMID: 23878190
- These results suggest that MIP-1beta is a novel key mediator, and the peripheral MIP-1beta-CCR5 axis contributes to neuropathic pain. PMID: 22528550
- results indicate that MIP-1beta is involved in the recruitment of bone marrow-derived monocyte lineage cells PMID: 21912378
- increased responsiveness of murine eosinophils to MIP-1beta is mediated by CCR5 receptor in mice PMID: 12050188
- macrophage inflammatory protein-1beta is a hypoxia-induced neutrophil survival factor. PMID: 15630139
- MIP-1beta is overexpressed, and VE-cadherin is underexpressed in heart transplant allografts compared with isografts PMID: 15897346
- Overproduction of MIP-1beta in chemokine (C-C motif) receptor 5-deficient mice after collagen II-immunization may contribute partially to the occurrence of arthritis PMID: 15967376
- The expression and role CXCL12 and CCL4 and their receptors (CXCR4 and CCR5) in regulating thymocyte migration in conjunction with extracellular matrix during acute T. cruzi infection are investigated. PMID: 16637021
- ATF3 appears to be part of a control mechanism that limits the amount of CCL4 released by macrophages, preventing excessive inflammation. PMID: 16982098
- Antibody neutralization of CCL4 abrogates the ability of T-cells from IL-4-treated NOD mice to transfer protection against type 1 diabetes. PMID: 17327452
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亚细胞定位：Secreted.
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蛋白家族：Intercrine beta (chemokine CC) family
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数据库链接：
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