USP10
USP10，即泛素特异性蛋白酶10，别名 KIAA0190、GC124997。它是一种去泛素化酶（DUBs）家族中的重要成员，主要在细胞质中定位，能够对多种蛋白质进行去泛素化修饰，从而调控它们的稳定性和功能。USP10的作用机制涉及其酶活性，通过特异性地切割泛素链，影响蛋白质的降解和信号转导。它参与调控细胞增殖、细胞周期、凋亡与自噬等生理过程，并且与多种蛋白质如p53、PCNA、MSH2、Notch及PTEN等的去泛素化有关。USP10在多种肿瘤的发生发展中扮演着重要角色。它可以通过稳定p53蛋白及其定位、调节DNA损伤的敏感性与稳定性、延长PTEN半衰期等方式影响癌症演进。USP10在宫颈癌、胃癌等癌症中发挥着抑癌作用，而在乳腺癌中可能具有促癌作用。
热销产品
USP10 Antibody (CSB-PA613516LA01HU)
验证数据
Western Blot
Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, A549 whole cell lysate, Rat liver tissue
All lanes: USP10 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 88, 93 kDa
Observed band size: 88 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA613516LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA613516LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunoprecipitating USP10 in A549 whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-PA613516LA01HU in A549 whole cell lysate.
For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA613516LA01HU (8μg) + A549 whole cell lysate (500μg)
Lane 3: A549 whole cell lysate (10μg)
USP10 Antibodies
USP10 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA025696GA01HU | USP10 Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA613516LA01HU | USP10 Antibody | Human, Rat | ELISA, WB, IHC, IF, IP |
| CSB-PA613516LB01HU | USP10 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA613516LC01HU | USP10 Antibody, FITC conjugated | Human | |
| CSB-PA613516LD01HU | USP10 Antibody, Biotin conjugated | Human | ELISA |
USP10 Proteins
USP10 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP613516HU CSB-EP613516HU CSB-BP613516HU CSB-MP613516HU CSB-EP613516HU-B |
Recombinant Human Ubiquitin carboxyl-terminal hydrolase 10 (USP10) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
