UBR5
UBR5，即泛素蛋白连接酶E3成分n-识别蛋白5，别名DD5、EDD、HYD、EDD1。UBR5属于HECT家族的E3泛素蛋白连接酶，具有HECT结构域，能够通过添加泛素来修饰蛋白质。UBR5能识别特定蛋白质的N端降解信号，并促进这些蛋白质的泛素化和随后的降解。UBR5参与DNA损伤反应、代谢、转录和凋亡的调节，是泛素-蛋白酶体系统（UPS）在癌症和发育过程中的关键调节因子。UBR5的异常表达或突变可能导致细胞内蛋白质的异常积累或降解，影响细胞的正常功能和生理平衡，为肿瘤增殖、转录调控和肿瘤免疫逃逸提供有利条件，最终促进肿瘤的发生。
热销产品
验证数据
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using EDD antibody.
Western blot analysis of extracts from A549 cells, using EDD antibody.
Western blot analysis of extracts from HeLa cells (Lane 2), A549 cells (Lane 3) and HepG2 cells (Lane 4), using EDD antiobdy. The lane on the left is treated with systhesized peptide.
UBR5 Antibodies
UBR5 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA083120 | UBR5 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA004376 | UBR5 Antibody | Human | IHC, ELISA |
UBR5 Proteins
UBR5 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP025520HU CSB-EP025520HU CSB-BP025520HU CSB-MP025520HU CSB-EP025520HU-B |
Recombinant Human E3 ubiquitin-protein ligase UBR5 (UBR5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBR5 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP720310RA CSB-EP720310RA CSB-BP720310RA CSB-MP720310RA CSB-EP720310RA-B |
Recombinant Rat E3 ubiquitin-protein ligase UBR5 (Ubr5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
UBR5 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP770457MO CSB-EP770457MO CSB-BP770457MO CSB-MP770457MO CSB-EP770457MO-B |
Recombinant Mouse E3 ubiquitin-protein ligase UBR5 (Ubr5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
