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UBAC2

UBAC2,即泛素化相关结构域蛋白2,别名FLJ26351、FLJ30001、FLJ30548、FLJ42413、PHGDHL1。它是由人类染色体13q32.3上的UBAC2基因编码的蛋白。UBAC2在多种细胞过程中发挥作用,包括内质网(ER)吞噬、炎症反应的负调节、肿瘤发生发展。其作用机制涉及与自噬体蛋白GABARAP的相互作用,通过微管亲和力调节激酶2(MARK2)磷酸化UBAC2的丝氨酸(S)223,促进其二聚化,从而促进ER的选择性降解。UBAC2通过影响ER吞噬,抑制炎症反应和急性溃疡性结肠炎(UC),并与多种肿瘤的发生和发展密切相关,如膀胱癌。UBAC2的异常表达与多种疾病相关,包括Behcet’sdisease、皮肤癌和膀胱癌,是潜在的治疗靶点和预后因素。

热销产品

UBAC2 Antibody (CSB-PA854093LA01HU)

验证数据

CSB-PA854093LA01HU

IHC image of CSB-PA854093LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA854093LA01HU

IHC image of CSB-PA854093LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

UBAC2 Antibodies

UBAC2 for Homo sapiens (Human)

UBAC2 Proteins

UBAC2 Proteins for Homo sapiens (Human)