TMED4
TMED4，即跨膜p24运输蛋白4。别名HNLF、ERS25、p24a3。TMED4在多种细胞过程中发挥作用，包括内质网应激反应、热休克反应、细胞凋亡以及囊泡蛋白运输，主要在早期分泌途径中。
TMED4的作用机制涉及内质网应激(ERS)的调节，通过IRE1α-XBP1信号通路和NRF2相关的抗氧化反应，促进调节性T细胞(Treg)中活性氧(ROS)的稳态，维持Treg细胞Foxp3的表达及抑制功能。TMED4对于维持Treg细胞的稳定性和功能至关重要，其缺失会导致Treg细胞中Foxp3稳定性降低，影响Treg细胞的抑制功能，进而可能导致T细胞过度激活和炎症反应加剧。TMED4还可能通过ER相关的降解(ERAD)系统抑制IRE1α的蛋白酶体降解。TMED4的功能异常与多种疾病相关，包括神经细胞脂褐素沉积症8型。
热销产品
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA639635(TMED4 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA639635(TMED4 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 8%SDS-PAGE,Lysate: 40 μg,Lane 1-5: HepG2 cells, K562 cells, Hela cells, A549 cells, Mouse intestines tissue,Primary antibody: CSB-PA639635(TMED4 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute
TMED4 Antibodies
TMED4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA023660GA01HU | TMED4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA639635 | TMED4 Antibody | Human,Mouse | ELISA,WB,IHC |
TMED4 Proteins
TMED4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP770365HU CSB-EP770365HU CSB-BP770365HU CSB-MP770365HU CSB-EP770365HU-B |
Recombinant Human Transmembrane emp24 domain-containing protein 4 (TMED4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
