TMED10
TMED10，即跨膜p24运输蛋白10，别名p23、TMP21、p24d1、S31I125、Tmp-21-I、S31III125、P24(DELTA)等。TMED10由人类TMED10基因编码，属于EMP24/GP25L/p24家族，是一种具有GOLD结构域的I型膜蛋白。TMED10定位于质膜和高尔基体池，并参与囊泡蛋白运输。此外，TMED10也是异聚分泌酶复合体的成员，能够调节复合体的γ-分泌酶活性而不会影响其ε-分泌酶活性。TMED10通过形成同源寡聚体调控一系列非经典分泌蛋白进入内质网-高尔基体中间体（ERGIC），这条途径被称为TMED10通道化的非经典分泌（THU），在调控IL-33分泌、维护肠稳态和神经稳态中发挥作用。TMED10的突变与早发性家族性阿尔茨海默病有关。
热销产品
TMED10 Antibody (CSB-PA023655ESR2HU)
验证数据
Western blot
All lanes: TMED10 antibody at 4.88µg/ml
Lane 1: Hela whole cell lysate
Lane 2: Mouse liver tissue
Lane 3: Mouse lung tissue
Lane 4: 293T whole cell lysate
Lane 5: NIH/3T3 whole cell lysate
Lane 6: U87 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 25 kDa
Observed band size: 25 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023655ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA023655ESR2HU at dilution of 1:100
TMED10 Antibodies
TMED10 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA023655GA01HU | TMED10 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA023655ESR2HU | TMED10 Antibody | Human, Mouse | ELISA, WB, IHC |
TMED10 Proteins
TMED10 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023655HU1 CSB-EP023655HU1 CSB-BP023655HU1 CSB-MP023655HU1 CSB-EP023655HU1-B |
Recombinant Human Transmembrane emp24 domain-containing protein 10 (TMED10), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023655HU | Recombinant Human Transmembrane emp24 domain-containing protein 10 (TMED10) | in vitro E.coli expression system |
