TET2
TET2，甲基胞嘧啶双加氧酶2，别名Ten-eleventranslocation2(TET-2)。它是一种α-酮戊二酸和Fe2+依赖的双加氧酶，主要来源于哺乳动物的TET蛋白家族，该家族包括TET1、TET2和TET3三个成员。TET2的作用机制是通过催化5-甲基胞嘧啶(5mC)氧化生成5-羟甲基胞嘧啶(5hmC)，进而通过一系列的氧化步骤最终转化为未修饰的胞嘧啶，这一过程是DNA主动去甲基化的重要途径。TET2在细胞命运决定、分化、肿瘤发生发展以及免疫调控中发挥重要作用。TET2的异常表达或突变与多种疾病相关，包括髓系肿瘤和免疫相关疾病。在肿瘤抑制方面，TET2通过调控基因表达和DNA甲基化状态，影响细胞增殖和分化。在免疫调控中，TET2能够影响炎症因子的分泌，参与炎症反应的调控。
热销产品
TET2 Antibody (CSB-PA764560ESR1HU)
验证数据
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA764560ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA764560ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA764560ESR1HU at dilution of 1:100
TET2 Antibodies
TET2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA023397GA01HU | TET2 Antibody | Human | ELISA,WB |
| CSB-PA764560ESR1HU | TET2 Antibody | Human | ELISA, IHC |
TET2 Proteins
TET2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP678395MO CSB-BP678395MO CSB-MP678395MO CSB-EP678395MO-B |
Recombinant Mouse Methylcytosine dioxygenase TET2 (Tet2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP678395MO | Recombinant Mouse Methylcytosine dioxygenase TET2 (Tet2), partial | E.coli |
TET2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP764560HU CSB-EP764560HU CSB-BP764560HU CSB-MP764560HU CSB-EP764560HU-B |
Recombinant Human Methylcytosine dioxygenase TET2 (TET2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
