TCF4
TCF4，即T细胞因子4，别名ITF2、E2-2、SEF-1。它是一种含有高迁移率族蛋白结构域的核转录因子，主要来源于哺乳动物的基因组。TCF4的作用机制主要是通过其高迁移率族蛋白结构域(HMG)结合DNA，与β-catenin形成转录复合体，调控Wnt信号通路中的靶基因表达。在生物学意义上，TCF4在细胞增殖、分化、迁移、极性化和凋亡中发挥重要作用，尤其在神经发育、肿瘤发生发展以及精神疾病中具有重要功能。TCF4的异常表达与多种疾病相关，包括精神分裂症、Pitt-Hopkins综合征以及某些类型的癌症。
热销产品
TCF4 Antibody (CSB-PA023302HA01HU)
验证数据
Western Blot
Positive WB detected in: Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue
All lanes: TCF4 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 72, 55, 49, 66, 65, 58, 68, 64, 70, 69, 63 kDa
Observed band size: 72 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA023302HA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA023302HA01HU at dilution of 1:100
TCF4 Antibodies
TCF4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA023302HA01HU | TCF4 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA023302HB01HU | TCF4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA023302HC01HU | TCF4 Antibody, FITC conjugated | Human | |
| CSB-PA023302HD01HU | TCF4 Antibody, Biotin conjugated | Human | ELISA |
TCF4 Proteins
TCF4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP023302HU CSB-EP023302HU CSB-BP023302HU CSB-MP023302HU CSB-EP023302HU-B |
Recombinant Human Transcription factor 4 (TCF4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
