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SYK

SYK,即脾酪氨酸激酶,别名KSYK、p72syk。SYK由人类SYK基因编码,该基因广泛表达于造血细胞中,并涉及将激活的免疫受体耦合到介导多种细胞反应的下游信号事件,包括增殖、分化和吞噬作用。SYK的作用机制涉及其作为非受体型Tyr蛋白激酶家族成员,在B细胞受体(BCR)反应中扮演中心角色,作为上游激活器激活PI3K、PLCgamma2和Rac/cdc42等途径。SYK在适应性免疫受体信号传导中发挥着至关重要的作用,并且近期研究显示SYK还介导其他多样化的生物学功能,包括细胞粘附、先天免疫识别、破骨细胞成熟、血小板活化和血管发育等。SYK在自身免疫性疾病和血液恶性肿瘤中也发挥着至关重要的作用。

热销产品

SYK Antibody (CSB-PA022998LA01HU)

验证数据

CSB-PA022998LA01HU

Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA022998LA01HU at dilution of 1:100

CSB-PA022998LA01HU

Immunofluorescence staining of HepG2 cells with CSB-PA022998LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

SYK Antibodies

SYK for Homo sapiens (Human)

SYK Proteins

SYK Proteins for Homo sapiens (Human)

SYK Proteins for Mus musculus (Mouse)

SYK Proteins for Gallus gallus (Chicken)

SYK Proteins for Rattus norvegicus (Rat)