STK40
STK40，即丝氨酸/苏氨酸激酶40，别名SHIK、SgK495。STK40是一种假激酶，具有激酶同源结构域但缺乏催化活性，主要通过作为支架蛋白协助E3泛素连接酶与底物蛋白结合，促进蛋白的泛素化和降解。STK40可调控Th1和Th17细胞的分化，介导炎症和自身免疫疾病进展中的重要功能，通过促进FOXO转录因子与E3连接酶COP1的相互作用，促进K48连接的多泛素化和蛋白酶体降解。STK40在多种生理过程中发挥作用，包括细胞分化、免疫反应调节以及可能的能量代谢调节，其异常表达与多种疾病相关，包括自身免疫性疾病和肿瘤。
热销产品
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA112765(STK40 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA112765(STK40 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: CSB-PA112765(STK40 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
STK40 Antibodies
STK40 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA112765 | STK40 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA158011 | STK40 Antibody | Human,Mouse,Rat | ELISA,IHC |
STK40 Proteins
STK40 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP854027HU CSB-EP854027HU CSB-BP854027HU CSB-MP854027HU CSB-EP854027HU-B |
Recombinant Human Serine/threonine-protein kinase 40 (STK40) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
