SREBF2
SREBF2，即固醇调节元件结合蛋白2，别名包括BHLHD2。SREBF2是一种关键的转录因子，主要在内质网膜上定位，通过感应胆固醇水平的变化来调节胆固醇代谢相关基因的表达。SREBP2的作用机制涉及其在内质网中的感受胆固醇变化，当胆固醇水平降低时，SREBP2从前体蛋白中被切割激活，然后转移到细胞核内，与固醇调节元件（SRE）结合，激活下游基因的转录，这些基因包括低密度脂蛋白受体（LDLR）、3-羟基-3-甲基戊二酰辅酶A还原酶（HMGCR）等，从而调节细胞内胆固醇的合成和摄取。SREBP2是维持胆固醇稳态的关键调控因子，对于细胞功能和机体健康至关重要。SREBP2的异常表达或活性失调可能导致多种代谢性疾病，包括动脉粥样硬化、非酒精性脂肪肝病（NAFLD）等。
热销产品
SREBF2 Antibody (CSB-PA666241LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA666241LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA666241LA01HU at dilution of 1:100
Immunofluorescence staining of Hela cells with CSB-PA666241LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
SREBF2 Antibodies
SREBF2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA022658GA01HU | SREBF2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA552311 | SREBF2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA549727 | SREBF2 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA666241LA01HU | SREBF2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA666241LC01HU | SREBF2 Antibody, FITC conjugated | Human | |
| CSB-PA666241LD01HU | SREBF2 Antibody, Biotin conjugated | Human | ELISA |
SREBF2 Proteins
SREBF2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP621515HU1 CSB-EP621515HU1 CSB-BP621515HU1 CSB-MP621515HU1 CSB-EP621515HU1-B |
Recombinant Human Sterol regulatory element-binding protein 2 (SREBF2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF621515HU | Recombinant Human Sterol regulatory element-binding protein 2 (SREBF2), partial | in vitro E.coli expression system |
