SPP1

SPP1蛋白全称分泌磷蛋白1，又称骨桥蛋白或OPN，是一种多功能糖蛋白，广泛存在于骨骼、免疫细胞及肿瘤微环境中。SPP1通过与整合素受体结合，参与调控细胞黏附、迁移及矿化过程，在骨折修复和血管钙化中具有双重调节作用。SPP1异常高表达与乳腺癌、肝癌等实体瘤转移密切相关，同时与多发性硬化症、动脉粥样硬化等慢性炎症性疾病进程存在显著关联。在骨质疏松患者中，血清SPP1水平可作为骨质流失的动态监测指标。
针对SPP1的治疗策略主要采用单克隆抗体中和其病理功能。人源化抗体KPL-404在类风湿性关节炎Ⅱ期试验中表现出抑制关节破坏的潜力，而siRNA药物STP705通过局部注射降低瘢痕疙瘩中SPP1表达量，已完成皮肤纤维化治疗的Ⅰ期安全性验证。某些天然多酚化合物被发现能阻断SPP1与CD44受体的相互作用，这为开发口服小分子抑制剂提供了新方向，但其生物利用度仍是当前研究瓶颈。

热销产品

Recombinant Human Osteopontin (SPP1) (CSB-MP022603HU(F5))

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SPP1 Recombinant Monoclonal Antibody (CSB-RA022603MA1HU)

验证数据

Overlay Peak curve showing A549 cells stained with CSB-RA022603MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*10⁶cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*10⁶cells) used under the same conditions. Acquisition of >10, 000 events was performed.

SPP1 Antibody

SPP1 Protein

SPP1 ELISA Kit

SPP1 Antibodies

SPP1 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA06904A0Rb	SPP1 Antibody	Human	ELISA, IHC
CSB-PA06904C0Rb	SPP1 Antibody, FITC conjugated	Human
CSB-PA06904D0Rb	SPP1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA06904B0Rb	SPP1 Antibody, HRP conjugated	Human	ELISA
CSB-PA827743	SPP1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA003599	SPP1 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA297038	SPP1 Antibody	Human	ELISA,WB,IHC
CSB-PA264573	SPP1 Antibody	Human,Mouse	ELISA,WB
CSB-RA261140A0HU	SPP1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC
CSB-RA022603MA1HU	SPP1 Recombinant Monoclonal Antibody	Human	ELISA, FC

SPP1 for Mus musculus (Mouse)

产品货号	产品名称	种属反应性	应用类型
CSB-PA022603YD01MO	Spp1 Antibody, Biotin conjugated	Mouse	ELISA
CSB-PA022603YA01MO	Spp1 Antibody	Mouse	ELISA, WB

SPP1 Proteins

SPP1 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP022603HU(F5)	Recombinant Human Osteopontin (SPP1)	Yeast
CSB-YP021198HU CSB-EP021198HU CSB-BP021198HU CSB-MP021198HU CSB-EP021198HU-B	Recombinant Human Sphingosine-1-phosphate phosphatase 1 (SGPP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP022603HU(F5)	Recombinant Human Osteopontin (SPP1)	Mammalian cell

SPP1 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP022603MO	Recombinant Mouse Osteopontin (Spp1), partial	Yeast
CSB-BP022603MO CSB-MP022603MO CSB-EP022603MO-B	Recombinant Mouse Osteopontin (Spp1), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Sus scrofa (Pig)

产品货号	产品名称	来源
CSB-YP022603PI CSB-EP022603PI CSB-BP022603PI CSB-MP022603PI CSB-EP022603PI-B	Recombinant Pig Osteopontin (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Bos taurus (Bovine)

产品货号	产品名称	来源
CSB-YP022603BO CSB-EP022603BO CSB-BP022603BO CSB-MP022603BO CSB-EP022603BO-B	Recombinant Bovine Osteopontin (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Gallus gallus (Chicken)

产品货号	产品名称	来源
CSB-YP022603CH CSB-EP022603CH CSB-BP022603CH CSB-MP022603CH CSB-EP022603CH-B	Recombinant Chicken Osteopontin (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Oryctolagus cuniculus (Rabbit)

产品货号	产品名称	来源
CSB-YP022603RB CSB-EP022603RB CSB-BP022603RB CSB-MP022603RB CSB-EP022603RB-B	Recombinant Rabbit Osteopontin (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP022603RA CSB-EP022603RA CSB-BP022603RA CSB-MP022603RA CSB-EP022603RA-B	Recombinant Rat Osteopontin (Spp1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

产品货号	产品名称	来源
CSB-YP527933SXV CSB-EP527933SXV CSB-BP527933SXV CSB-MP527933SXV CSB-EP527933SXV-B	Recombinant Schizosaccharomyces pombe Set1 complex component spp1 (spp1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Nicotiana tabacum (Common tobacco)

产品货号	产品名称	来源
CSB-YP708413NHE CSB-EP708413NHE CSB-BP708413NHE CSB-MP708413NHE CSB-EP708413NHE-B	Recombinant Nicotiana tabacum Sucrose-phosphatase 1 (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Oryza sativa subsp. japonica (Rice)

产品货号	产品名称	来源
CSB-YP842478OFG CSB-EP842478OFG CSB-BP842478OFG CSB-MP842478OFG CSB-EP842478OFG-B	Recombinant Oryza sativa subsp. japonica Probable sucrose-phosphatase 1 (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

产品货号	产品名称	来源
CSB-YP863231DOA CSB-EP863231DOA CSB-BP863231DOA CSB-MP863231DOA CSB-EP863231DOA-B	Recombinant Arabidopsis thaliana Probable sucrose-phosphatase 1 (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Zea mays (Maize)

产品货号	产品名称	来源
CSB-YP884318ZAX CSB-EP884318ZAX CSB-BP884318ZAX CSB-MP884318ZAX CSB-EP884318ZAX-B	Recombinant Zea mays Sucrose-phosphatase 1 (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Ovis aries (Sheep)

产品货号	产品名称	来源
CSB-YP893170SH CSB-EP893170SH CSB-BP893170SH CSB-MP893170SH CSB-EP893170SH-B	Recombinant Sheep Osteopontin (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli