SPA17
SPA17全称为精子发生相关蛋白17,也被称为SP17或CT37,最初在男性生殖细胞中被发现,主要参与精子形成及受精过程中的透明带结合。SPA17在卵巢癌、肺癌、多发性骨髓瘤等多种恶性肿瘤中异常高表达,通过增强细胞迁移能力和促进血管生成参与肿瘤进展。其分子机制涉及调控细胞外基质重塑相关蛋白水解酶活性,并与整合素信号网络形成交互作用,可能影响肿瘤细胞对微环境的适应性。目前针对SPA17的抗体药物及多肽疫苗已进入临床前研究阶段,特别是在卵巢癌治疗领域,利用其肿瘤特异性表达的免疫治疗策略展现出潜力。有研究发现靶向SPA17的CAR-T细胞疗法在动物实验中成功抑制了肿瘤转移,同时被证实与免疫逃逸相关,其阻断剂可能成为联合PD-1抑制剂的新型治疗方案。
热销产品
Recombinant Human Sperm surface protein Sp17 (SPA17), partial (CSB-EP614892HU1)
验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP121244h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SPA17.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP121244h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SPA17.
SPA17 Antibody (CSB-PA12124A0Rb)
验证数据

IHC image of CSB-PA12124A0Rb diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA12124A0Rb diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
SPA17 Antibodies
SPA17 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA022451GA01HU | SPA17 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA12124A0Rb | SPA17 Antibody | Human | ELISA, IHC |
CSB-PA12124C0Rb | SPA17 Antibody, FITC conjugated | Human |
SPA17 Proteins
SPA17 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-EP614892HU1 | Recombinant Human Sperm surface protein Sp17 (SPA17), partial | E.coli |
CSB-YP614892HU CSB-EP614892HU CSB-BP614892HU CSB-MP614892HU CSB-EP614892HU-B |
Recombinant Human Sperm surface protein Sp17 (SPA17) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |