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SPA17

SPA17全称为精子发生相关蛋白17,也被称为SP17或CT37,最初在男性生殖细胞中被发现,主要参与精子形成及受精过程中的透明带结合。SPA17在卵巢癌、肺癌、多发性骨髓瘤等多种恶性肿瘤中异常高表达,通过增强细胞迁移能力和促进血管生成参与肿瘤进展。其分子机制涉及调控细胞外基质重塑相关蛋白水解酶活性,并与整合素信号网络形成交互作用,可能影响肿瘤细胞对微环境的适应性。目前针对SPA17的抗体药物及多肽疫苗已进入临床前研究阶段,特别是在卵巢癌治疗领域,利用其肿瘤特异性表达的免疫治疗策略展现出潜力。有研究发现靶向SPA17的CAR-T细胞疗法在动物实验中成功抑制了肿瘤转移,同时被证实与免疫逃逸相关,其阻断剂可能成为联合PD-1抑制剂的新型治疗方案。

热销产品

Recombinant Human Sperm surface protein Sp17 (SPA17), partial (CSB-EP614892HU1)

验证数据

CSB-EP614892HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP614892HU1

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP121244h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SPA17.

CSB-EP614892HU1

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-RP121244h could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) SPA17.

SPA17 Antibody (CSB-PA12124A0Rb)

验证数据

CSB-PA12124A0Rb

IHC image of CSB-PA12124A0Rb diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA12124A0Rb

IHC image of CSB-PA12124A0Rb diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

SPA17 Antibodies

SPA17 for Homo sapiens (Human)

SPA17 Proteins

SPA17 Proteins for Homo sapiens (Human)