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SOST

SOST,即硬化蛋白,别名Sclerostin、VBCH。它是一种由SOST基因编码的分泌型糖蛋白,属于Cerberus/Dan家族的骨形态发生蛋白(BMP)拮抗剂。SOST在骨骼系统中由骨细胞产生,具有抗骨形成作用。其作用机制主要是通过与LRP5/6受体结合,抑制Wnt信号通路,从而对骨形成产生抑制作用。SOST对维持骨稳态、骨密度维持和骨折愈合等方面至关重要,其异常表达与多种骨骼疾病相关,包括骨质疏松症、骨折愈合障碍以及遗传性骨疾病如硬化性骨病和van Buchem病等,是治疗代谢性骨病和促进骨折修复的潜在治疗靶点。

热销产品

SOST Recombinant Monoclonal Antibody (CSB-RA858415MA1HU)

验证数据

CSB-RA858415MA1HU

IHC image of CSB-RA858415MA1HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA858415MA1HU

IHC image of CSB-RA858415MA1HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

Human Sclerostin(SOST) ELISA Kit (CSB-E13146h)

验证数据

CSB-E13146h 标准曲线

货号:CSB-E13146h

规格:96T/48T

灵敏度:7.8 pg/mL

检测范围:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

SOST Antibodies

SOST for Homo sapiens (Human)

SOST Proteins

SOST Proteins for Mus musculus (Mouse)

SOST Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

SOST Proteins for Homo sapiens (Human)

SOST Proteins for Rattus norvegicus (Rat)

SOST Proteins for Bos taurus (Bovine)

SOST ELISA Kit

SOST ELISA Kit for Homo sapiens (Human)

SOST ELISA Kit for Rattus norvegicus (Rat)