SOST
SOST,即硬化蛋白,别名Sclerostin、VBCH。它是一种由SOST基因编码的分泌型糖蛋白,属于Cerberus/Dan家族的骨形态发生蛋白(BMP)拮抗剂。SOST在骨骼系统中由骨细胞产生,具有抗骨形成作用。其作用机制主要是通过与LRP5/6受体结合,抑制Wnt信号通路,从而对骨形成产生抑制作用。SOST对维持骨稳态、骨密度维持和骨折愈合等方面至关重要,其异常表达与多种骨骼疾病相关,包括骨质疏松症、骨折愈合障碍以及遗传性骨疾病如硬化性骨病和van Buchem病等,是治疗代谢性骨病和促进骨折修复的潜在治疗靶点。
热销产品
SOST Recombinant Monoclonal Antibody (CSB-RA858415MA1HU)
验证数据

IHC image of CSB-RA858415MA1HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA858415MA1HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
Human Sclerostin(SOST) ELISA Kit (CSB-E13146h)
验证数据

货号:CSB-E13146h
规格:96T/48T
灵敏度:7.8 pg/mL
检测范围:31.25 pg/mL-2000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
SOST Antibodies
SOST for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA858415ESR1HU | SOST Antibody | Human | ELISA, IHC |
CSB-PA858415ESR2HU | SOST Antibody | Human | ELISA, WB, IHC |
CSB-PA020254 | SOST Antibody | Human | WB, ELISA |
CSB-RA858415MA1HU | SOST Recombinant Monoclonal Antibody | Human | ELISA, IHC |
SOST Proteins
SOST Proteins for Mus musculus (Mouse)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP858168MO CSB-EP858168MO CSB-EP858168MO-B |
Recombinant Mouse Sclerostin (Sost) | Yeast E.coli In Vivo Biotinylation in E.coli |
CSB-BP858168MO | Recombinant Mouse Sclerostin (Sost) | Baculovirus |
CSB-MP858168MO | Recombinant Mouse Sclerostin (Sost) | Mammalian cell |
SOST Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP858374DSU CSB-EP858374DSU CSB-BP858374DSU CSB-MP858374DSU CSB-EP858374DSU-B |
Recombinant Chlorocebus aethiops Sclerostin (SOST) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SOST Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP858415HU CSB-EP858415HU CSB-BP858415HU CSB-MP858415HU CSB-EP858415HU-B |
Recombinant Human Sclerostin (SOST) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP858415HU-B | Recombinant Human Sclerostin (SOST), Biotinylated | Mammalian cell |
SOST Proteins for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP859165RA CSB-EP859165RA-B |
Recombinant Rat Sclerostin (Sost) | Yeast In Vivo Biotinylation in E.coli |
CSB-EP859165RA | Recombinant Rat Sclerostin (Sost) | E.coli |
CSB-BP859165RA | Recombinant Rat Sclerostin (Sost) | Baculovirus |
CSB-MP859165RA | Recombinant Rat Sclerostin (Sost) | Mammalian cell |
SOST Proteins for Bos taurus (Bovine)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP860205BO CSB-EP860205BO CSB-BP860205BO CSB-MP860205BO CSB-EP860205BO-B |
Recombinant Bovine Sclerostin (SOST) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SOST ELISA Kit
SOST ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-E13146h | Human Sclerostin(SOST) ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
SOST ELISA Kit for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-EL022415RA | Rat Sclerostin(SOST) ELISA kit | serum, plasma, tissue homogenates | 4.68 pg/mL |