SMARCA2
SMARCA2全称为SWI/SNF相关基质相关肌动蛋白依赖的染色质调控因子A2，也被称为BRM或SNF2L2。SMARCA2属于SWI/SNF染色质重塑复合物核心成员，通过调节染色质结构动态变化影响基因转录活性，在细胞分化、增殖及DNA损伤修复中起关键作用。SMARCA2功能异常与肺癌、肝癌、卵巢癌等多种实体瘤密切相关，其表达缺失可能导致肿瘤抑制因子失活或致癌通路异常激活。近年来针对SMARCA2的药物开发聚焦于表观遗传调控领域，例如利用PROTAC技术开发靶向降解剂，或通过抑制其ATP酶活性恢复抑癌功能。
热销产品
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SMARCA2 Antibody (CSB-PA021799LA01HU)
验证数据
Chromatin Immunoprecipitation Hela (1.1*106) were cross-linked with formaldehyde, sonicated, and immunoprecipitated with 4µg anti-SMARCA2 or a control normal rabbit IgG. The resulting ChIP DNA was quantified using real-time PCR with primers (CSB-PP021799HU) against the ESR1 pS2 promoter.
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA021799LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA021799LA01HU at dilution of 1:100
SMARCA2 Antibodies
SMARCA2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA021799LA01HU | SMARCA2 Antibody | Human | ELISA, IHC, ChIP |
| CSB-PA021799LD01HU | SMARCA2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA004649 | SMARCA2 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA253060 | SMARCA2 Antibody | Human | ELISA,IHC |
| CSB-PA822578 | SMARCA2 Antibody | Human | ELISA,IHC |
SMARCA2 Proteins
SMARCA2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP021799HU | Recombinant Human Probable global transcription activator SNF2L2 (SMARCA2), partial | Yeast |
| CSB-EP021799HU | Recombinant Human Probable global transcription activator SNF2L2 (SMARCA2), partial | E.coli |
| CSB-BP021799HU CSB-MP021799HU |
Recombinant Human Probable global transcription activator SNF2L2 (SMARCA2), partial | Baculovirus Mammalian cell |
| CSB-EP021799HU-B | Recombinant Human Probable global transcription activator SNF2L2 (SMARCA2), partial,Biotinylated | E.coli |
| CSB-MP021799HU4 | Recombinant Human Probable global transcription activator SNF2L2 (SMARCA2), partial | Mammalian cell |
| CSB-EP021799HU1 | Recombinant Human Probable global transcription activator SNF2L2 (SMARCA2), partial | E.coli |
| CSB-EP021799HU1a0 | Recombinant Human Probable global transcription activator SNF2L2 (SMARCA2), partial | E.coli |
