SLC6A19
SLC6A19,即溶质载体家族6成员19,别名HND、B0AT1。它是一种在人类肠道和肾脏上皮细胞中表达的跨膜蛋白,负责将中性氨基酸从细胞外转运到细胞内。SLC6A19的作用机制是通过主动转运,将氨基酸从肠道吸收并在肾脏中重吸收。该基因的突变可能导致Hartnup病,这是一种遗传性疾病,表现为糙皮病、小脑性共济失调和精神病等症状。SLC6A19在氨基酸稳态、糖尿病和体重控制中也扮演着重要角色。在肠道细胞中的表达和功能依赖于辅助蛋白血管紧张素转换酶2(ACE2)的存在,ACE2也是SARS-CoV-2的细胞受体之一。
热销产品
SLC6A19 Antibody (CSB-PA731656LA01HU)
验证数据

IHC image of CSB-PA731656LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA731656LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA731656LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
SLC6A19 Antibodies
SLC6A19 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA129068 | SLC6A19 Antibody | Human | ELISA,IHC |
CSB-PA180070 | SLC6A19 Antibody | Human | ELISA,IHC |
CSB-PA731656LA01HU | SLC6A19 Antibody | Human | ELISA, IHC, IF |
CSB-PA731656LB01HU | SLC6A19 Antibody, HRP conjugated | Human | ELISA |
CSB-PA731656LC01HU | SLC6A19 Antibody, FITC conjugated | Human | |
CSB-PA731656LD01HU | SLC6A19 Antibody, Biotin conjugated | Human | ELISA |
SLC6A19 Proteins
SLC6A19 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP731656HU CSB-EP731656HU CSB-BP731656HU CSB-MP731656HU CSB-EP731656HU-B |
Recombinant Human Sodium-dependent neutral amino acid transporter B (0)AT1 (SLC6A19), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |