SCN10A
SCN10A，别名PN3、peripheral nerve sodium channel 3等。它是由人类SCN10A基因编码的蛋白质，位于3号染色体上。SCN10A的作用机制是通过形成电压门控钠通道，调节钠离子的流动，特别是在痛觉信号的传递和心脏电生理活动中发挥作用。SCN10A在神经细胞如背根神经节的nociceptors中表达，参与疼痛信号的传递；在心脏中，SCN10A可能参与心律的调节，其变异与心脏传导障碍如Brugada综合征有关。SCN10A的突变或异常表达与多种疼痛障碍、心律失常等疾病相关，是研究和治疗这些疾病的潜在靶点。
热销产品
SCN10A Antibody (CSB-PA750910LA01HU)
验证数据
Immunofluorescence staining of SH-SY5Y cells with CSB-PA750910LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
SCN10A Antibodies
SCN10A for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA251062 | SCN10A Antibody | Human | ELISA,IHC |
| CSB-PA146616 | SCN10A Antibody | Human | ELISA,IHC |
| CSB-PA750910LA01HU | SCN10A Antibody | Human | ELISA, IF |
| CSB-PA750910LB01HU | SCN10A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA750910LC01HU | SCN10A Antibody, FITC conjugated | Human | |
| CSB-PA750910LD01HU | SCN10A Antibody, Biotin conjugated | Human | ELISA |
