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RIPK4

RIPK4,即受体相互作用蛋白激酶4,别名DIK、PKK。它是由人类基因组中的RIPK4基因编码的蛋白,属于受体相互作用蛋白激酶(RIPK)家族成员之一。RIPK4在多种细胞过程中发挥作用,包括细胞死亡、炎症反应、皮肤分化、皮肤炎症、皮肤伤口修复以及氧化应激和铁死亡的调控。其作用机制涉及调节多种信号通路,如NF-κB、Wnt/β-catenin和RAF/MEK/ERK通路,以及通过影响ACSM1的表达来调节脂质代谢,从而影响氧化应激和铁死亡。RIPK4在调控细胞命运、维持组织稳态、参与皮肤和肠道屏障功能以及在多种疾病中发挥重要作用,包括癌症、急性肾损伤、神经退行性疾病等。RIPK4的异常表达与多种疾病相关,如鳞状细胞癌、Bartsocas-Papas综合征等,使其成为潜在的治疗靶点和预后因素。

热销产品

RIPK4 Antibody (CSB-PA436282)

验证数据

CSB-PA436282

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA436282(RIPK4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA436282

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA436282(RIPK4 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

RIPK4 Antibodies

RIPK4 for Homo sapiens (Human)

RIPK4 Proteins

RIPK4 Proteins for Homo sapiens (Human)