PTAFR
血小板激活因子受体（Platelet-Activating Factor Receptor，PAFR）是一种G蛋白偶联受体，广泛分布于血小板、中性粒细胞及血管内皮细胞表面。该受体因介导炎症级联反应而闻名，当与配体PAF结合后，可触发细胞内钙离子释放并激活磷脂酶C，进而促进血管通透性增高、白细胞趋化及血小板活化。其异常活化与急性呼吸窘迫综合征、过敏性休克、动脉粥样硬化等病理过程密切相关，在脓毒症中常作为促炎介质加剧全身炎症反应。
目前全球已开发多款PAFR拮抗剂，如昔帕芬旦（TCV-309）和来帕泛（Lexipafant）曾进入败血症临床试验，但因疗效未达预期而终止。近年研究转向该受体在肿瘤微环境中的作用，发现其通过调控NF-κB通路促进乳腺癌转移，相关小分子抑制剂正在临床前评估中。某些抗组胺药物被发现具有非特异性PAFR阻断效应，这为哮喘等过敏性疾病治疗提供了新的联合用药思路。
热销产品
PTAFR Antibody (CSB-PA018946LA01HU)
验证数据
Western blot
All lanes: PTAFR antibody at 4µg/ml + Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 40 kDa
Observed band size: 40 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018946LA01HU at dilution of 1:100
Immunofluorescent analysis of A431 cells using CSB-PA018946LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunofluorescent analysis of HepG2 cells using CSB-PA018946LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
PTAFR Antibodies
PTAFR for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA040050 | PTAFR Antibody | Human,Mouse,Rat | IF, ELISA |
| CSB-PA109839 | PTAFR Antibody | Human | ELISA,IHC |
| CSB-PA018946LA01HU | PTAFR Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA018946LB01HU | PTAFR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018946LC01HU | PTAFR Antibody, FITC conjugated | Human | |
| CSB-PA018946LD01HU | PTAFR Antibody, Biotin conjugated | Human | ELISA |
PTAFR Proteins
PTAFR Proteins for Cavia porcellus (Guinea pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018946GU1 CSB-EP018946GU1 CSB-BP018946GU1 CSB-MP018946GU1 CSB-EP018946GU1-B |
Recombinant Guinea pig Platelet-activating factor receptor (PTAFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946GU | Recombinant Guinea pig Platelet-activating factor receptor (PTAFR) | in vitro E.coli expression system |
PTAFR Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018946HU1 CSB-EP018946HU1 CSB-BP018946HU1 CSB-MP018946HU1 CSB-EP018946HU1-B |
Recombinant Human Platelet-activating factor receptor (PTAFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946HU | Recombinant Human Platelet-activating factor receptor (PTAFR) | in vitro E.coli expression system |
PTAFR Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018946RA1 CSB-EP018946RA1 CSB-BP018946RA1 CSB-MP018946RA1 CSB-EP018946RA1-B |
Recombinant Rat Platelet-activating factor receptor (Ptafr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946RA | Recombinant Rat Platelet-activating factor receptor (Ptafr) | in vitro E.coli expression system |
PTAFR Proteins for Macaca mulatta (Rhesus macaque)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018946MOW1 CSB-EP018946MOW1 CSB-BP018946MOW1 CSB-MP018946MOW1 CSB-EP018946MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) Platelet-activating factor receptor (PTAFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946MOW | Recombinant Macaca mulatta (Rhesus macaque) Platelet-activating factor receptor (PTAFR) | in vitro E.coli expression system |
PTAFR Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018946MO1 CSB-EP018946MO1 CSB-BP018946MO1 CSB-MP018946MO1 CSB-EP018946MO1-B |
Recombinant Mouse Platelet-activating factor receptor (Ptafr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946MO | Recombinant Mouse Platelet-activating factor receptor (Ptafr) | in vitro E.coli expression system |
PTAFR Proteins for Capra hircus (Goat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018946GO1 CSB-EP018946GO1 CSB-BP018946GO1 CSB-MP018946GO1 CSB-EP018946GO1-B |
Recombinant Goat Platelet-activating factor receptor (PTAFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946GO | Recombinant Goat Platelet-activating factor receptor (PTAFR) | in vitro E.coli expression system |
PTAFR Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018946BO1 CSB-EP018946BO1 CSB-BP018946BO1 CSB-MP018946BO1 CSB-EP018946BO1-B |
Recombinant Bovine Platelet-activating factor receptor (PTAFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946BO | Recombinant Bovine Platelet-activating factor receptor (PTAFR) | in vitro E.coli expression system |
PTAFR Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018946PI1 CSB-EP018946PI1 CSB-BP018946PI1 CSB-MP018946PI1 CSB-EP018946PI1-B |
Recombinant Pig Platelet-activating factor receptor (PTAFR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF018946PI | Recombinant Pig Platelet-activating factor receptor (PTAFR) | in vitro E.coli expression system |
