PRMT5
PRMT5，即蛋白精氨酸甲基转移酶5，它是一种在多种组织中广泛表达的酶，参与蛋白质的翻译后修饰。PRMT5的作用机制是通过催化特定蛋白质底物上的精氨酸残基发生甲基化，从而调控蛋白质的结构、功能和稳定性。这种甲基化修饰在细胞信号传导、基因表达调控、细胞周期控制等生物学过程中起着关键作用。PRMT5的异常活性与多种疾病相关，包括癌症、神经退行性疾病和心血管疾病，被认为是药物开发的潜在靶点。
热销产品
PRMT5 Recombinant Monoclonal Antibody (CSB-RA176962A0HU)
验证数据
Western Blot
Positive WB detected in: Raji whole cell lysate, Hela whole cell lysate, HL60 whole cell lysate, Jurkat whole cell lysate, A549 whole cell lysate
All lanes: PRMT5 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 73, 72, 54, 68, 67 kDa
Observed band size: 73 kDa
IHC image of CSB-RA176962A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
PRMT5 Antibodies
PRMT5 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA018734GA01HU | PRMT5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA077190 | PRMT5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA107290 | PRMT5 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA018734LA01HU | PRMT5 Antibody | Human | ELISA, IHC, IF |
| CSB-PA018734LB01HU | PRMT5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018734LC01HU | PRMT5 Antibody, FITC conjugated | Human | |
| CSB-RA176962A0HU | PRMT5 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
PRMT5 Proteins
PRMT5 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018734HU CSB-EP018734HU CSB-BP018734HU CSB-MP018734HU CSB-EP018734HU-B |
Recombinant Human Protein arginine N-methyltransferase 5 (PRMT5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
