PNPLA3
PNPLA3，即含patatin样磷脂酶结构域3，别名Adpn、C22orf20、iPLA(2)epsilon。PNPLA3是一种非特异性脂肪酰基水解酶，属于patatin样磷脂酶家族的非分泌性蛋白。它具有1-酰基甘油-3-磷酸O-酰基转移酶活性、长链脂肪酸CoA结合活性以及溶血磷脂酸结合活性。PNPLA3主要调节甘油脂质代谢、长链脂肪酸代谢以及饮食过量反应，主要定位于脂滴和细胞膜中，并在左肺、嗅觉上皮和右肺中表达。PNPLA3在非酒精性脂肪肝病（NAFLD）中起重要作用，与冠状动脉疾病、多种肝病和2型糖尿病相关。PNPLA3基因多态性与NAFLD的严重程度相关，其变异可能影响肝脏中脂质的正常代谢和异常积累，从而参与脂肪性肝病的发生和发展。
热销产品
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PNPLA3 Antibody (CSB-PA889106ESR1HU)
验证数据
Western blot
All lanes: Patatin-like phospholipase domain-containing protein 3 antibody at 8μg/ml + HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 53 kDa
Observed band size: 53 kDa
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA889106ESR1HU at dilution of 1:100
PNPLA3 Antibodies
PNPLA3 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA889106ESR1HU | PNPLA3 Antibody | Human | ELISA, WB, IHC |
| CSB-PA154215 | PNPLA3 Antibody | Human, Mouse | WB, ELISA |
PNPLA3 Proteins
PNPLA3 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP889106HU CSB-BP889106HU CSB-MP889106HU CSB-EP889106HU-B |
Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP889106HU | Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3), partial | E.coli |
| CSB-MP889106HU(A4)(M) | Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3) ((I148M)) | Mammalian cell |
| CSB-BP889106HU(A4)(M)c7 | Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3)(I148M) | Baculovirus |
| CSB-BP889106HU(A4)(M)d7 | Recombinant Human 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3) (I148M) | Baculovirus |
