PIK3CG
PIK3CG，即磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基γ，别名PI3Kγ、p110γ、p120-PI3K等。它是一种由PIK3CG基因编码的蛋白质，属于磷脂酰肌醇3-激酶(PI3K)家族的类I催化亚基之一。PIK3CG在多种细胞类型中表达，尤其在免疫细胞中高度表达。其作用机制主要是通过与p85调节亚基结合形成PI3K复合体，进而催化磷脂酰肌醇-4,5-二磷酸(PIP2)转化为磷脂酰肌醇-3,4,5-三磷酸(PIP3)，这一过程在细胞信号传导中发挥关键作用。PIK3CG在生物学上的意义非常广泛，它参与调节多种细胞生理过程，包括细胞生长、存活、代谢和迁移等。PIK3CG的功能异常与多种疾病有关，特别是与免疫相关疾病和癌症的发生发展密切相关。例如，PIK3CG的突变或表达失调可能影响免疫细胞的激活和功能，进而影响炎症反应和自身免疫疾病。此外，PIK3CG在某些癌症中的异常激活可能促进肿瘤细胞的增殖、侵袭和转移。因此，PIK3CG是药物开发和疾病治疗中的一个潜在靶点。
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验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PIK3CG Antibody (CSB-PA827787)
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA827787(PIK3CG Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA827787(PIK3CG Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
PIK3CG Antibodies
PIK3CG for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA030057 | PIK3CG Antibody | Human | WB, IHC, ELISA |
| CSB-PA877253 | PIK3CG Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA827787 | PIK3CG Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA13309A0Rb | PIK3CG Antibody | Human | ELISA, IF |
| CSB-PA13309B0Rb | PIK3CG Antibody, HRP conjugated | Human | ELISA |
| CSB-PA13309D0Rb | PIK3CG Antibody, Biotin conjugated | Human | ELISA |
PIK3CG Proteins
PIK3CG Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018001HU CSB-BP018001HU CSB-MP018001HU CSB-EP018001HU-B |
Recombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018001HU | Recombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG), partial | E.coli |
PIK3CG Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018001PI CSB-EP018001PI CSB-BP018001PI CSB-MP018001PI CSB-EP018001PI-B |
Recombinant Pig Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PIK3CG Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP878048MO CSB-EP878048MO CSB-BP878048MO CSB-MP878048MO CSB-EP878048MO-B |
Recombinant Mouse Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Pik3cg), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
