PGLYRP1
肽聚糖识别蛋白1(PGLYRP1)是一种先天性免疫系统的重要效应分子,也被称为PGRP-S或Tag7。该蛋白能够特异性识别细菌细胞壁的肽聚糖成分,通过直接结合病原微生物触发杀菌活性,例如诱导溶菌酶释放或破坏细菌膜结构。其功能不依赖传统免疫细胞介导,在皮肤、呼吸道和肠道等屏障组织中广泛表达,构成人体抵御感染的第一道防线。
PGLYRP1的表达异常与多种炎症性疾病相关。在类风湿性关节炎患者的关节滑液中可检测到该蛋白水平升高,其促炎特性可能加剧关节损伤。相反,银屑病和炎症性肠病患者病灶部位常出现PGLYRP1表达下调,提示其免疫调节功能的缺失。近年来,基于该蛋白的双向调控特性,科学家正探索其在脓毒症和癌症中的治疗潜力。例如,利用重组PGLYRP1增强抗生素疗效的研究已进入临床前阶段,而针对其促癌转移活性的单抗药物也在开发中,为免疫相关疾病提供了新的干预思路。
热销产品
Recombinant Human Peptidoglycan recognition protein 1 (PGLYRP1) (CSB-EP017862HU)
验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PGLYRP1 Antibody (CSB-PA017862LA01HU)
验证数据

IHC image of CSB-PA017862LA01HU diluted at 1:300 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA017862LA01HU diluted at 1:300 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
PGLYRP1 Antibodies
PGLYRP1 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA603901 | PGLYRP1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA281298 | PGLYRP1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA406529 | PGLYRP1 Antibody | Human | WB, ELISA |
CSB-PA017862LA01HU | PGLYRP1 Antibody | Human | ELISA, IHC |
CSB-PA017862LB01HU | PGLYRP1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA017862LC01HU | PGLYRP1 Antibody, FITC conjugated | Human | |
CSB-PA017862LD01HU | PGLYRP1 Antibody, Biotin conjugated | Human | ELISA |
PGLYRP1 Proteins
PGLYRP1 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP017862HU CSB-BP017862HU CSB-MP017862HU CSB-EP017862HU-B |
Recombinant Human Peptidoglycan recognition protein 1 (PGLYRP1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP017862HU | Recombinant Human Peptidoglycan recognition protein 1 (PGLYRP1) | E.coli |