P2RX3

P2RX3，即嘌呤能受体P2X配体门控离子通道3型蛋白，常被称为P2X3受体，别名P2X3。P2RX3属于ATP门控的非选择性阳离子通道家族，主要分布于感觉神经元末梢，通过与胞外ATP结合触发钠、钙离子内流，参与痛觉信号传导及内脏器官的神经反射调控。研究发现，其过度激活与慢性咳嗽、膀胱过度活动症及糖尿病神经病变密切相关，在神经源性炎症和内脏超敏反应中起关键作用。近年来针对P2X3受体的药物开发取得突破，如首个高选择性拮抗剂Gefapixant（AF-219）已完成Ⅲ期临床试验，证实能显著改善难治性慢性咳嗽患者症状，但存在味觉障碍副作用。另有Eliapixant（BAY-1817080）等二代药物通过结构优化降低不良反应，目前处于Ⅱ期研究阶段。该靶点同时被探索用于治疗间质性膀胱炎和神经病理性疼痛，其双重拮抗剂（同时阻断P2X2/3异源三聚体）在肠易激综合征等疾病中展现出潜在治疗价值。

热销产品

P2RX3 Antibody (CSB-PA017321ESR1HU)

验证数据

Western blot
All lanes: P2RX3 antibody at 3.91 μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 44 kDa
Observed band size: 44 kDa

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA017321ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA017321ESR1HU at dilution of 1:100

P2RX3 Antibody

P2RX3 Protein

P2RX3 Antibodies

P2RX3 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA005140	P2RX3 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA056352	P2RX3 Antibody	Human	ELISA,WB,IHC
CSB-PA017321ESR1HU	P2RX3 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA017321ESR2HU	P2RX3 Antibody	Human	ELISA, IHC

P2RX3 Proteins

P2RX3 Proteins for Rattus norvegicus (Rat)

产品货号	产品名称	来源
CSB-YP017321RA CSB-EP017321RA CSB-BP017321RA CSB-MP017321RA CSB-EP017321RA-B	Recombinant Rat P2X purinoceptor 3 (P2rx3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

P2RX3 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP017321HU CSB-EP017321HU CSB-BP017321HU CSB-MP017321HU CSB-EP017321HU-B	Recombinant Human P2X purinoceptor 3 (P2RX3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

P2RX3 Proteins for Mus musculus (Mouse)

产品货号	产品名称	来源
CSB-YP663676MO CSB-EP663676MO CSB-BP663676MO CSB-MP663676MO CSB-EP663676MO-B	Recombinant Mouse P2X purinoceptor 3 (P2rx3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli