OTUD3
OTUD3，即OTU结构域含蛋白3，别名OTUD7B、JAMM-2、JAMM2等。它是一种由OTUD3基因编码的蛋白质，属于OTU蛋白酶家族成员，在细胞内具有去泛素化酶活性。OTUD3的作用机制涉及其OTU结构域，该结构域赋予了它特异性去除蛋白质上泛素化修饰的能力，参与调控蛋白质的稳定性和信号传导过程。OTUD3的功能异常与多种疾病有关，包括某些类型的癌症、神经退行性疾病等。研究表明，OTUD3通过去泛素化修饰影响p53蛋白的稳定性，进而影响细胞对DNA损伤的响应。此外，OTUD3还在免疫细胞中发挥作用，调节炎症反应和细胞因子的产生。因此，OTUD3是细胞生物学和疾病研究中的一个重要分子靶点。
热销产品
OTUD3 Antibody (CSB-PA719399LA01HU)
验证数据
Western Blot
Positive WB detected in: U251 whole cell lysate, U87 whole cell lysate
All lanes: OTUD3 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46 kDa
Observed band size: 46 kDa
Immunofluorescence staining of U251 cells with CSB-PA719399LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
OTUD3 Antibodies
OTUD3 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA719399LA01HU | OTUD3 Antibody | Human | ELISA, WB, IF |
| CSB-PA719399LB01HU | OTUD3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA719399LC01HU | OTUD3 Antibody, FITC conjugated | Human | |
| CSB-PA719399LD01HU | OTUD3 Antibody, Biotin conjugated | Human | ELISA |
OTUD3 Proteins
OTUD3 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP719399HU CSB-EP719399HU CSB-BP719399HU CSB-MP719399HU CSB-EP719399HU-B |
Recombinant Human OTU domain-containing protein 3 (OTUD3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
